topA_1 protein (Legionella waltersii) - STRING interaction network

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topA_1

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (759 aa)

Predicted Functional Partners:

recQ

0.985

leuS

0.954

Ssb_1

0.953

Ssb_2

0.953

Ssb_4

0.953

Ssb_3

0.953

korA

0.927

polA

0.856

Lwal_3157

0.846

recA

0.842

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lwal_3157	korA	Lwal_3157	Lwal_0129	Potassium efflux system KefA.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.550
Lwal_3157	polA	Lwal_3157	Lwal_2334	Potassium efflux system KefA.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.952
Lwal_3157	recA	Lwal_3157	Lwal_1804	Potassium efflux system KefA.	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.893
Lwal_3157	recQ	Lwal_3157	Lwal_0331	Potassium efflux system KefA.	ATP-dependent DNA helicase RecQ.	0.963
Lwal_3157	topA_1	Lwal_3157	Lwal_1259	Potassium efflux system KefA.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.846
Ssb_1	polA	Lwal_0937	Lwal_2334	Single strand DNA binding protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.621
Ssb_1	topA_1	Lwal_0937	Lwal_1259	Single strand DNA binding protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.953
Ssb_2	polA	Lwal_1626	Lwal_2334	Single strand DNA binding protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.613
Ssb_2	topA_1	Lwal_1626	Lwal_1259	Single strand DNA binding protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.953
Ssb_3	polA	Lwal_2406	Lwal_2334	Single strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.648
Ssb_3	topA_1	Lwal_2406	Lwal_1259	Single strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.953
Ssb_4	polA	Lwal_1725	Lwal_2334	Single strand DNA binding protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.619
Ssb_4	topA_1	Lwal_1725	Lwal_1259	Single strand DNA binding protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.953
korA	Lwal_3157	Lwal_0129	Lwal_3157	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Potassium efflux system KefA.	0.550
korA	leuS	Lwal_0129	Lwal_0825	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.475
korA	recA	Lwal_0129	Lwal_1804	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.516
korA	topA_1	Lwal_0129	Lwal_1259	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.927
leuS	korA	Lwal_0825	Lwal_0129	leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.475
leuS	polA	Lwal_0825	Lwal_2334	leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.587
leuS	recA	Lwal_0825	Lwal_1804	leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.496

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