glnK protein (Legionella waltersii) - STRING interaction network

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Score

glnK

Carbamoylphosphate synthase large subunit; Belongs to the P(II) protein family. (112 aa)

Predicted Functional Partners:

glnD

0.879

YqiC

0.616

Lwal_0256

0.565

GlnE

0.551

nadE

0.525

glnA

0.524

Gmr_3

0.509

Cph2_6

0.509

Gmr_4

0.509

YrrB

0.488

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cph2_6	Gmr_3	Lwal_3024	Lwal_2767	Inner membrane protein.	Regulatory protein (GGDEF domain).	0.995
Cph2_6	Gmr_4	Lwal_3024	Lwal_3050	Inner membrane protein.	GGDEF domain-containing sensory box protein.	0.995
Cph2_6	Lwal_0256	Lwal_3024	Lwal_0256	Inner membrane protein.	Methyltransferase.	0.679
Cph2_6	YrrB	Lwal_3024	Lwal_1420	Inner membrane protein.	Methyltransferase.	0.552
Cph2_6	glnD	Lwal_3024	Lwal_1888	Inner membrane protein.	protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.416
Cph2_6	glnK	Lwal_3024	Lwal_1444	Inner membrane protein.	Carbamoylphosphate synthase large subunit; Belongs to the P(II) protein family.	0.509
Cph2_6	nadE	Lwal_3024	Lwal_2842	Inner membrane protein.	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.539
GlnE	glnA	Lwal_2796	Lwal_0812	Adenylyl transferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]	Glutamine synthetase.	0.751
GlnE	glnD	Lwal_2796	Lwal_1888	Adenylyl transferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]	protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.825
GlnE	glnK	Lwal_2796	Lwal_1444	Adenylyl transferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]	Carbamoylphosphate synthase large subunit; Belongs to the P(II) protein family.	0.551
GlnE	nadE	Lwal_2796	Lwal_2842	Adenylyl transferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...]	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.509
Gmr_3	Cph2_6	Lwal_2767	Lwal_3024	Regulatory protein (GGDEF domain).	Inner membrane protein.	0.995
Gmr_3	Gmr_4	Lwal_2767	Lwal_3050	Regulatory protein (GGDEF domain).	GGDEF domain-containing sensory box protein.	0.994
Gmr_3	Lwal_0256	Lwal_2767	Lwal_0256	Regulatory protein (GGDEF domain).	Methyltransferase.	0.679
Gmr_3	YrrB	Lwal_2767	Lwal_1420	Regulatory protein (GGDEF domain).	Methyltransferase.	0.552
Gmr_3	glnD	Lwal_2767	Lwal_1888	Regulatory protein (GGDEF domain).	protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.416
Gmr_3	glnK	Lwal_2767	Lwal_1444	Regulatory protein (GGDEF domain).	Carbamoylphosphate synthase large subunit; Belongs to the P(II) protein family.	0.509
Gmr_3	nadE	Lwal_2767	Lwal_2842	Regulatory protein (GGDEF domain).	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.539
Gmr_4	Cph2_6	Lwal_3050	Lwal_3024	GGDEF domain-containing sensory box protein.	Inner membrane protein.	0.995
Gmr_4	Gmr_3	Lwal_3050	Lwal_2767	GGDEF domain-containing sensory box protein.	Regulatory protein (GGDEF domain).	0.994