Lwal_1528 protein (Legionella waltersii) - STRING interaction network

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Lwal_1528

Endonuclease/Exonuclease/phosphatase family protein. (429 aa)

Predicted Functional Partners:

polA

0.870

birA

0.824

nth

0.819

dnaN

0.813

mutY

0.778

ung

0.725

RluE

0.677

rluB

0.677

hfq

0.670

holB

0.660

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lwal_1528	RluE	Lwal_1528	Lwal_0281	Endonuclease/Exonuclease/phosphatase family protein.	Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.	0.677
Lwal_1528	birA	Lwal_1528	Lwal_0248	Endonuclease/Exonuclease/phosphatase family protein.	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	0.824
Lwal_1528	dnaN	Lwal_1528	Lwal_2212	Endonuclease/Exonuclease/phosphatase family protein.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.813
Lwal_1528	hfq	Lwal_1528	Lwal_2219	Endonuclease/Exonuclease/phosphatase family protein.	Protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	0.670
Lwal_1528	holB	Lwal_1528	Lwal_0777	Endonuclease/Exonuclease/phosphatase family protein.	DNA polymerase III subunit delta'.	0.660
Lwal_1528	mutY	Lwal_1528	Lwal_0364	Endonuclease/Exonuclease/phosphatase family protein.	A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.778
Lwal_1528	nth	Lwal_1528	Lwal_2107	Endonuclease/Exonuclease/phosphatase family protein.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.819
Lwal_1528	polA	Lwal_1528	Lwal_2334	Endonuclease/Exonuclease/phosphatase family protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.870
Lwal_1528	rluB	Lwal_1528	Lwal_0726	Endonuclease/Exonuclease/phosphatase family protein.	Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.	0.677
Lwal_1528	ung	Lwal_1528	Lwal_1499	Endonuclease/Exonuclease/phosphatase family protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.725
RluE	Lwal_1528	Lwal_0281	Lwal_1528	Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.	Endonuclease/Exonuclease/phosphatase family protein.	0.677
RluE	rluB	Lwal_0281	Lwal_0726	Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.	Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.	0.409
birA	Lwal_1528	Lwal_0248	Lwal_1528	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Endonuclease/Exonuclease/phosphatase family protein.	0.824
birA	hfq	Lwal_0248	Lwal_2219	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	0.481
birA	mutY	Lwal_0248	Lwal_0364	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.545
dnaN	Lwal_1528	Lwal_2212	Lwal_1528	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Endonuclease/Exonuclease/phosphatase family protein.	0.813
dnaN	holB	Lwal_2212	Lwal_0777	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	DNA polymerase III subunit delta'.	0.999
dnaN	mutY	Lwal_2212	Lwal_0364	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.612
dnaN	polA	Lwal_2212	Lwal_2334	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.994
dnaN	ung	Lwal_2212	Lwal_1499	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.797