drrA_2 protein (Legionella waltersii) - STRING interaction network

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Score

drrA_2

Multifunctional virulence effector protein DrrA. (319 aa)

Predicted Functional Partners:

dnaK

0.968

EryA

0.941

Lwal_2663

0.922

htpG

0.909

grpE

0.823

rplQ

0.752

ppiB

0.751

rplM

0.738

rplO

0.738

rplK

0.733

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EryA	Lwal_2663	Lwal_0942	Lwal_2663	Polyketide synthase module.	Saframycin Mx1 synthetase B.	0.999
EryA	dnaK	Lwal_0942	Lwal_0550	Polyketide synthase module.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.634
EryA	drrA_2	Lwal_0942	Lwal_1573	Polyketide synthase module.	Multifunctional virulence effector protein DrrA.	0.941
EryA	grpE	Lwal_0942	Lwal_0551	Polyketide synthase module.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.442
EryA	htpG	Lwal_0942	Lwal_0808	Polyketide synthase module.	Heat shock protein 90; Molecular chaperone. Has ATPase activity.	0.697
EryA	ppiB	Lwal_0942	Lwal_1401	Polyketide synthase module.	Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.951
EryA	rplK	Lwal_0942	Lwal_0967	Polyketide synthase module.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.950
EryA	rplM	Lwal_0942	Lwal_1380	Polyketide synthase module.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.971
EryA	rplO	Lwal_0942	Lwal_2399	Polyketide synthase module.	50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.926
EryA	rplQ	Lwal_0942	Lwal_2405	Polyketide synthase module.	50S ribosomal protein L17.	0.934
Lwal_2663	EryA	Lwal_2663	Lwal_0942	Saframycin Mx1 synthetase B.	Polyketide synthase module.	0.999
Lwal_2663	dnaK	Lwal_2663	Lwal_0550	Saframycin Mx1 synthetase B.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.505
Lwal_2663	drrA_2	Lwal_2663	Lwal_1573	Saframycin Mx1 synthetase B.	Multifunctional virulence effector protein DrrA.	0.922
Lwal_2663	grpE	Lwal_2663	Lwal_0551	Saframycin Mx1 synthetase B.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.406
Lwal_2663	ppiB	Lwal_2663	Lwal_1401	Saframycin Mx1 synthetase B.	Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.927
Lwal_2663	rplK	Lwal_2663	Lwal_0967	Saframycin Mx1 synthetase B.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.927
Lwal_2663	rplM	Lwal_2663	Lwal_1380	Saframycin Mx1 synthetase B.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.965
Lwal_2663	rplO	Lwal_2663	Lwal_2399	Saframycin Mx1 synthetase B.	50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.925
Lwal_2663	rplQ	Lwal_2663	Lwal_2405	Saframycin Mx1 synthetase B.	50S ribosomal protein L17.	0.934
dnaK	EryA	Lwal_0550	Lwal_0942	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Polyketide synthase module.	0.634