pucG protein (Legionella waltersii) - STRING interaction network

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Score

pucG

Purine catabolism protein PucG. (379 aa)

Predicted Functional Partners:

gcvT

0.942

glyA

0.941

aceB

0.939

DgdA_2

0.938

gcvPB

0.920

gcvH

0.919

TdcG

0.914

ald

0.912

kbl

0.912

prpB_1

0.911

Your Current Organism:

Legionella waltersii

NCBI taxonomy Id: 66969
Other names: ATCC 51914, CCUG 44924, CIP 104965, DSM 21908, L. waltersii, NCTC 13017, strain 2074-AUS-E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DgdA_2	aceB	Lwal_1768	Lwal_0457	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Malate synthase A.	0.803
DgdA_2	ald	Lwal_1768	Lwal_0391	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Alanine dehydrogenase; Belongs to the AlaDH/PNT family.	0.900
DgdA_2	gcvPB	Lwal_1768	Lwal_2345	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	0.910
DgdA_2	glyA	Lwal_1768	Lwal_2834	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.907
DgdA_2	kbl	Lwal_1768	Lwal_2816	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	0.903
DgdA_2	prpB_1	Lwal_1768	Lwal_0456	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	2-methylisocitrate lyase.	0.800
DgdA_2	pucG	Lwal_1768	Lwal_3204	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Purine catabolism protein PucG.	0.938
TdcG	gcvH	Lwal_0260	Lwal_2348	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.417
TdcG	gcvPB	Lwal_0260	Lwal_2345	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	0.492
TdcG	gcvT	Lwal_0260	Lwal_2349	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.	0.503
TdcG	glyA	Lwal_0260	Lwal_2834	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.965
TdcG	pucG	Lwal_0260	Lwal_3204	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Purine catabolism protein PucG.	0.914
aceB	DgdA_2	Lwal_0457	Lwal_1768	Malate synthase A.	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.803
aceB	prpB_1	Lwal_0457	Lwal_0456	Malate synthase A.	2-methylisocitrate lyase.	0.999
aceB	pucG	Lwal_0457	Lwal_3204	Malate synthase A.	Purine catabolism protein PucG.	0.939
ald	DgdA_2	Lwal_0391	Lwal_1768	Alanine dehydrogenase; Belongs to the AlaDH/PNT family.	Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.900
ald	pucG	Lwal_0391	Lwal_3204	Alanine dehydrogenase; Belongs to the AlaDH/PNT family.	Purine catabolism protein PucG.	0.912
gcvH	TdcG	Lwal_2348	Lwal_0260	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.417
gcvH	gcvPB	Lwal_2348	Lwal_2345	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	0.999
gcvH	gcvT	Lwal_2348	Lwal_2349	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.	0.999