node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KOH18253.1 | KOH18254.1 | ACZ92_19140 | ACZ92_19145 | DedD; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.935 |
KOH18253.1 | accD-2 | ACZ92_19140 | ACZ92_19150 | DedD; Derived by automated computational analysis using gene prediction method: Protein Homology. | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.665 |
KOH18253.1 | truA | ACZ92_19140 | ACZ92_19155 | DedD; Derived by automated computational analysis using gene prediction method: Protein Homology. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.456 |
KOH18254.1 | KOH18253.1 | ACZ92_19145 | ACZ92_19140 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DedD; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.935 |
KOH18254.1 | KOH19512.1 | ACZ92_19145 | ACZ92_14920 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.929 |
KOH18254.1 | KOH22431.1 | ACZ92_19145 | ACZ92_07320 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formate--tetrahydrofolate ligase; Catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.786 |
KOH18254.1 | accD-2 | ACZ92_19145 | ACZ92_19150 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.841 |
KOH18254.1 | folE | ACZ92_19145 | ACZ92_22130 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.736 |
KOH18254.1 | folK-2 | ACZ92_19145 | ACZ92_20695 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.898 |
KOH18254.1 | folP | ACZ92_19145 | ACZ92_20490 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.992 |
KOH18254.1 | glyA | ACZ92_19145 | ACZ92_12605 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.716 |
KOH18254.1 | thyA | ACZ92_19145 | ACZ92_15795 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.858 |
KOH18254.1 | truA | ACZ92_19145 | ACZ92_19155 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.723 |
KOH19512.1 | KOH18254.1 | ACZ92_14920 | ACZ92_19145 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.929 |
KOH19512.1 | KOH22431.1 | ACZ92_14920 | ACZ92_07320 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formate--tetrahydrofolate ligase; Catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
KOH19512.1 | glyA | ACZ92_14920 | ACZ92_12605 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.930 |
KOH19512.1 | thyA | ACZ92_14920 | ACZ92_15795 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
KOH22431.1 | KOH18254.1 | ACZ92_07320 | ACZ92_19145 | Formate--tetrahydrofolate ligase; Catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.786 |
KOH22431.1 | KOH19512.1 | ACZ92_07320 | ACZ92_14920 | Formate--tetrahydrofolate ligase; Catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
KOH22431.1 | folP | ACZ92_07320 | ACZ92_20490 | Formate--tetrahydrofolate ligase; Catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.406 |