STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (381 aa)    
Predicted Functional Partners:
ANP71097.1
Protoporphyrinogen oxidase; Pfam:pfam13450 NAD(P)-binding Rossmann-like domain.
 
 
 0.998
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.990
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.984
ANP71104.1
Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.953
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.945
ANP72049.1
Pfam:pfam02602 Uroporphyrinogen-III synthase HemD.
  
 
 0.938
ANP72050.1
uroporphyrin-III methyltransferase; Pfam:pfam00590 Tetrapyrrole (Corrin/Porphyrin) Methylases.
    
 0.918
ANP73130.1
uroporphyrin-III methyltransferase; Pfam:pfam00590 Tetrapyrrole (Corrin/Porphyrin) Methylases.
    
 0.918
ANP71105.1
Pfam:pfam00490 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.888
ANP72779.1
Glutamate synthase; Pfam:pfam01645 Conserved region in glutamate synthase.
     
 0.830
Your Current Organism:
Cryobacterium arcticum
NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1
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