STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANP71666.1Inosine 5''''-monophosphate dehydrogenase; Pfam:pfam00478 IMP dehydrogenase / GMP reductase domain. (479 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.972
ANP71196.1
Pfam:pfam00117 Glutamine amidotransferase class-I.
  
 
 0.940
ANP72357.1
Glutamine amidotransferase.
  
 
 0.940
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Pfam:pfam01808 AICARFT/IMPCHase bienzyme.
  
 
 0.938
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
  
0.931
ANP71907.1
NTP phosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.922
ANP74079.1
Hypoxanthine phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.913
ANP73835.1
Inosine 5''''-monophosphate dehydrogenase; Pfam:pfam00478 IMP dehydrogenase / GMP reductase domain.
   
0.906
ANP73316.1
Nucleoside triphosphate hydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain.
     
  0.900
Your Current Organism:
Cryobacterium arcticum
NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.