STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANP72199.1Thioredoxin; Pfam:pfam00085 Thioredoxin. (166 aa)    
Predicted Functional Partners:
ANP72201.1
Thioredoxin reductase; Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase.
 
 0.926
ANP72196.1
Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain.
 
 
 0.906
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.889
ANP74734.1
Thioredoxin reductase; Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase.
 
 0.886
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
  
 0.885
clpB
ATP-dependent Clp protease ATP-binding protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.839
ANP72200.1
Zinc finger, UBP-type; Pfam:pfam02148 Zn-finger in ubiquitin-hydrolases and other protein.
       0.809
ANP72197.1
Pfam:pfam13591 MerR HTH family regulatory protein.
     
 0.802
ANP72222.1
Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase.
 
 0.649
groL
Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.639
Your Current Organism:
Cryobacterium arcticum
NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.