node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANP71618.1 | ANP72785.1 | PA27867_0650 | PA27867_1832 | Pfam:pfam00535 Glycosyl transferase family 2. | Peptidase; Pfam:pfam09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp). | 0.596 |
ANP72783.1 | ANP72784.1 | PA27867_1830 | PA27867_1831 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Hypothetical protein. | 0.848 |
ANP72783.1 | ANP72785.1 | PA27867_1830 | PA27867_1832 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Peptidase; Pfam:pfam09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp). | 0.700 |
ANP72783.1 | hisE | PA27867_1830 | PA27867_1837 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.575 |
ANP72783.1 | hisF | PA27867_1830 | PA27867_1835 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.791 |
ANP72783.1 | hisG | PA27867_1830 | PA27867_1836 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.747 |
ANP72783.1 | hisI | PA27867_1830 | PA27867_1834 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.768 |
ANP72783.1 | trpA | PA27867_1830 | PA27867_1828 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.999 |
ANP72783.1 | trpB | PA27867_1830 | PA27867_1829 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.999 |
ANP72783.1 | trpE | PA27867_1830 | PA27867_1833 | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. | 0.999 |
ANP72784.1 | ANP72783.1 | PA27867_1831 | PA27867_1830 | Hypothetical protein. | Pfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.848 |
ANP72784.1 | ANP72785.1 | PA27867_1831 | PA27867_1832 | Hypothetical protein. | Peptidase; Pfam:pfam09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp). | 0.748 |
ANP72784.1 | hisE | PA27867_1831 | PA27867_1837 | Hypothetical protein. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.498 |
ANP72784.1 | hisF | PA27867_1831 | PA27867_1835 | Hypothetical protein. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.694 |
ANP72784.1 | hisG | PA27867_1831 | PA27867_1836 | Hypothetical protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.599 |
ANP72784.1 | hisI | PA27867_1831 | PA27867_1834 | Hypothetical protein. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.700 |
ANP72784.1 | trpA | PA27867_1831 | PA27867_1828 | Hypothetical protein. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.847 |
ANP72784.1 | trpB | PA27867_1831 | PA27867_1829 | Hypothetical protein. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.847 |
ANP72784.1 | trpE | PA27867_1831 | PA27867_1833 | Hypothetical protein. | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. | 0.671 |
ANP72785.1 | ANP71618.1 | PA27867_1832 | PA27867_0650 | Peptidase; Pfam:pfam09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp). | Pfam:pfam00535 Glycosyl transferase family 2. | 0.596 |