STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANP73723.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (302 aa)    
Predicted Functional Partners:
ANP72910.1
Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family.
 
 0.996
ANP73765.1
Pfam:pfam01063 Aminotransferase class IV.
 
 
 0.933
ANP74076.1
Dihydropteroate synthase; Pfam:pfam00809 Pterin binding enzyme.
  
  
0.926
folE
Pfam:pfam01227 GTP cyclohydrolase I.
  
 0.926
ANP73722.1
Deaminase; Pfam:pfam01872 RibD C-terminal domain.
 
   
 0.898
ANP73724.1
Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase.
       0.623
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
  
 0.611
ANP70996.1
Para-aminobenzoate synthase; Pfam:pfam00117 Glutamine amidotransferase class-I.
 
  
 0.539
ANP72569.1
Anthranilate synthase; Pfam:pfam00425 chorismate binding enzyme.
 
  
 0.505
ANP72355.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.466
Your Current Organism:
Cryobacterium arcticum
NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.