ANP74104.1 protein (Cryobacterium arcticum) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ANP74104.1

Hypothetical protein; Pfam:pfam13313 Domain of unknown function (DUF4082). (1332 aa)

Predicted Functional Partners:

ANP74100.1

0.920

ANP74101.1

0.916

ANP74094.1

0.910

ANP74105.1

0.905

ANP74099.1

0.904

ANP74102.1

0.878

ANP74096.1

0.777

ANP74085.1

0.772

ANP74097.1

0.756

ANP74089.1

0.753

Your Current Organism:

Cryobacterium arcticum

NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANP74085.1	ANP74089.1	PA27867_3155	PA27867_3159	Hypothetical protein.	Pfam:pfam00534 Glycosyl transferases group 1.	0.786
ANP74085.1	ANP74094.1	PA27867_3155	PA27867_3164	Hypothetical protein.	Hypothetical protein; Pfam:pfam13425 O-antigen ligase like membrane protein.	0.757
ANP74085.1	ANP74099.1	PA27867_3155	PA27867_3169	Hypothetical protein.	Glycosyl transferase; Pfam:pfam01943 Polysaccharide biosynthesis protein.	0.493
ANP74085.1	ANP74100.1	PA27867_3155	PA27867_3170	Hypothetical protein.	Pfam:pfam00534 Glycosyl transferases group 1.	0.447
ANP74085.1	ANP74101.1	PA27867_3155	PA27867_3171	Hypothetical protein.	Acyltransferase.	0.490
ANP74085.1	ANP74104.1	PA27867_3155	PA27867_3174	Hypothetical protein.	Hypothetical protein; Pfam:pfam13313 Domain of unknown function (DUF4082).	0.772
ANP74085.1	ANP74105.1	PA27867_3155	PA27867_3175	Hypothetical protein.	Oxidoreductase; Pfam:pfam01408 Oxidoreductase family, NAD-binding Rossmann fold.	0.528
ANP74089.1	ANP74085.1	PA27867_3159	PA27867_3155	Pfam:pfam00534 Glycosyl transferases group 1.	Hypothetical protein.	0.786
ANP74089.1	ANP74094.1	PA27867_3159	PA27867_3164	Pfam:pfam00534 Glycosyl transferases group 1.	Hypothetical protein; Pfam:pfam13425 O-antigen ligase like membrane protein.	0.628
ANP74089.1	ANP74096.1	PA27867_3159	PA27867_3166	Pfam:pfam00534 Glycosyl transferases group 1.	Glycosyl transferase group 1.	0.536
ANP74089.1	ANP74099.1	PA27867_3159	PA27867_3169	Pfam:pfam00534 Glycosyl transferases group 1.	Glycosyl transferase; Pfam:pfam01943 Polysaccharide biosynthesis protein.	0.729
ANP74089.1	ANP74100.1	PA27867_3159	PA27867_3170	Pfam:pfam00534 Glycosyl transferases group 1.	Pfam:pfam00534 Glycosyl transferases group 1.	0.421
ANP74089.1	ANP74101.1	PA27867_3159	PA27867_3171	Pfam:pfam00534 Glycosyl transferases group 1.	Acyltransferase.	0.557
ANP74089.1	ANP74102.1	PA27867_3159	PA27867_3172	Pfam:pfam00534 Glycosyl transferases group 1.	Pfam:pfam01041 DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family.	0.533
ANP74089.1	ANP74104.1	PA27867_3159	PA27867_3174	Pfam:pfam00534 Glycosyl transferases group 1.	Hypothetical protein; Pfam:pfam13313 Domain of unknown function (DUF4082).	0.753
ANP74089.1	ANP74105.1	PA27867_3159	PA27867_3175	Pfam:pfam00534 Glycosyl transferases group 1.	Oxidoreductase; Pfam:pfam01408 Oxidoreductase family, NAD-binding Rossmann fold.	0.691
ANP74094.1	ANP74085.1	PA27867_3164	PA27867_3155	Hypothetical protein; Pfam:pfam13425 O-antigen ligase like membrane protein.	Hypothetical protein.	0.757
ANP74094.1	ANP74089.1	PA27867_3164	PA27867_3159	Hypothetical protein; Pfam:pfam13425 O-antigen ligase like membrane protein.	Pfam:pfam00534 Glycosyl transferases group 1.	0.628
ANP74094.1	ANP74096.1	PA27867_3164	PA27867_3166	Hypothetical protein; Pfam:pfam13425 O-antigen ligase like membrane protein.	Glycosyl transferase group 1.	0.901
ANP74094.1	ANP74097.1	PA27867_3164	PA27867_3167	Hypothetical protein; Pfam:pfam13425 O-antigen ligase like membrane protein.	Pfam:pfam00535 Glycosyl transferase family 2.	0.889

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.728

expected number of edges:

13

PPI enrichment p-value:

0.00398

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006811

Ion transport

7 of 67

1.54

2.24

3.35e-07

GO:0055072

Iron ion homeostasis

2 of 5

2.12

0.93

0.0180

GO:0098662

Inorganic cation transmembrane transport

3 of 33

1.48

0.84

0.0160

GO:0065007

Biological regulation

8 of 482

0.74

0.55

0.0039

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046915

Transition metal ion transmembrane transporter activity

3 of 8

2.1

1.57

0.00093

GO:0046914

Transition metal ion binding

6 of 87

1.36

1.48

5.35e-05

GO:0015093

Ferrous iron transmembrane transporter activity

2 of 2

2.52

1.21

0.0060

GO:0046872

Metal ion binding

7 of 381

0.79

0.57

0.0060

GO:0043167

Ion binding

9 of 779

0.58

0.43

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2881

Mixed, incl. Ferrous iron transporter FeoA domain, and Phosphoglycerate mutase family

4 of 12

2.04

2.07

6.66e-05

CL:6577

Mixed, incl. Iron transport, and Ferrous iron transporter FeoA domain

2 of 6

2.04

0.71

0.0483

CL:2883

Ferrous iron transporter FeoA domain, and Iron transport

2 of 5

2.12

0.71

0.0483

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0410

Iron transport

2 of 2

2.52

1.12

0.0089

KW-0408

Iron

3 of 45

1.35

0.7

0.0292

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07670

Nucleoside recognition

3 of 3

2.52

2.0

0.00019

PF07664

Ferrous iron transport protein B C terminus

3 of 3

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030389

FeoB-type guanine nucleotide-binding (G) domain

3 of 3

2.52

1.8

0.00046

IPR011642

Nucleoside transporter/FeoB GTPase, Gate domain

3 of 3

2.52

1.8

0.00046

IPR011640

Ferrous iron transport protein B, C-terminal

3 of 3

2.52

1.8

0.00046

IPR038157

Ferrous iron transporter, core domain

3 of 4

2.4

1.78

0.00046

IPR007167

Ferrous iron transporter FeoA domain

3 of 4

2.4

1.78

0.00046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00899

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria. This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble ...

3 of 4

2.4

2.19

7.40e-05

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