STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANP74332.1Pfam:pfam00285 Citrate synthase. (263 aa)    
Predicted Functional Partners:
ANP71665.1
Alpha-ketoglutarate decarboxylase; Pfam:pfam00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain).
  
 
 0.981
ANP72864.1
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.979
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.968
ANP74707.1
Branched-chain alpha-keto acid dehydrogenase subunit E2; Pfam:pfam00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain).
  
 0.950
acsA
Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.946
ANP72368.1
AMP-dependent synthetase; Pfam:pfam00501 AMP-binding enzyme.
  
 0.946
ANP74270.1
Acetate--CoA ligase; Pfam:pfam00501 AMP-binding enzyme.
  
 0.946
ANP71285.1
Pfam:pfam01274 Malate synthase; Belongs to the malate synthase family.
   
 0.945
mqo
Pfam:pfam06039 Malate:quinone oxidoreductase (Mqo).
  
 
 0.930
ANP72519.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.926
Your Current Organism:
Cryobacterium arcticum
NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1
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