node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANP72196.1 | ANP74435.1 | PA27867_1230 | PA27867_3512 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Pfam:pfam13411 MerR HTH family regulatory protein. | 0.734 |
ANP72196.1 | dnaK | PA27867_1230 | PA27867_1228 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.992 |
ANP72196.1 | dnaK-2 | PA27867_1230 | PA27867_3515 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.971 |
ANP72196.1 | groL | PA27867_1230 | PA27867_2789 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.802 |
ANP72196.1 | grpE | PA27867_1230 | PA27867_1229 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.988 |
ANP72196.1 | grpE-2 | PA27867_1230 | PA27867_3514 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.859 |
ANP72196.1 | hrcA | PA27867_1230 | PA27867_1628 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.720 |
ANP74435.1 | ANP72196.1 | PA27867_3512 | PA27867_1230 | Pfam:pfam13411 MerR HTH family regulatory protein. | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | 0.734 |
ANP74435.1 | ANP74436.1 | PA27867_3512 | PA27867_3513 | Pfam:pfam13411 MerR HTH family regulatory protein. | Molecular chaperone DnaJ; Pfam:pfam00226 DnaJ domain. | 0.937 |
ANP74435.1 | dnaJ | PA27867_3512 | PA27867_1629 | Pfam:pfam13411 MerR HTH family regulatory protein. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.711 |
ANP74435.1 | dnaK | PA27867_3512 | PA27867_1228 | Pfam:pfam13411 MerR HTH family regulatory protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.665 |
ANP74435.1 | dnaK-2 | PA27867_3512 | PA27867_3515 | Pfam:pfam13411 MerR HTH family regulatory protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.921 |
ANP74435.1 | groL | PA27867_3512 | PA27867_2789 | Pfam:pfam13411 MerR HTH family regulatory protein. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.627 |
ANP74435.1 | grpE | PA27867_3512 | PA27867_1229 | Pfam:pfam13411 MerR HTH family regulatory protein. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.805 |
ANP74435.1 | grpE-2 | PA27867_3512 | PA27867_3514 | Pfam:pfam13411 MerR HTH family regulatory protein. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.954 |
ANP74435.1 | hrcA | PA27867_3512 | PA27867_1628 | Pfam:pfam13411 MerR HTH family regulatory protein. | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.721 |
ANP74435.1 | sigA | PA27867_3512 | PA27867_1706 | Pfam:pfam13411 MerR HTH family regulatory protein. | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.598 |
ANP74436.1 | ANP74435.1 | PA27867_3513 | PA27867_3512 | Molecular chaperone DnaJ; Pfam:pfam00226 DnaJ domain. | Pfam:pfam13411 MerR HTH family regulatory protein. | 0.937 |
ANP74436.1 | dnaK | PA27867_3513 | PA27867_1228 | Molecular chaperone DnaJ; Pfam:pfam00226 DnaJ domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.973 |
ANP74436.1 | dnaK-2 | PA27867_3513 | PA27867_3515 | Molecular chaperone DnaJ; Pfam:pfam00226 DnaJ domain. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.993 |