node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANP72196.1 | ANP72333.1 | PA27867_1230 | PA27867_1376 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | 0.600 |
ANP72196.1 | ANP74435.1 | PA27867_1230 | PA27867_3512 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Pfam:pfam13411 MerR HTH family regulatory protein. | 0.734 |
ANP72196.1 | clpB | PA27867_1230 | PA27867_1232 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | ATP-dependent Clp protease ATP-binding protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.923 |
ANP72196.1 | dnaK-2 | PA27867_1230 | PA27867_3515 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.971 |
ANP72196.1 | groL | PA27867_1230 | PA27867_2789 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.802 |
ANP72196.1 | groS | PA27867_1230 | PA27867_2905 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.676 |
ANP72196.1 | grpE | PA27867_1230 | PA27867_1229 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.988 |
ANP72196.1 | grpE-2 | PA27867_1230 | PA27867_3514 | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.859 |
ANP72333.1 | ANP72196.1 | PA27867_1376 | PA27867_1230 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | 0.600 |
ANP72333.1 | ANP74435.1 | PA27867_1376 | PA27867_3512 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Pfam:pfam13411 MerR HTH family regulatory protein. | 0.425 |
ANP72333.1 | ANP74436.1 | PA27867_1376 | PA27867_3513 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Pfam:pfam00226 DnaJ domain. | 0.600 |
ANP72333.1 | dnaJ | PA27867_1376 | PA27867_1629 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.600 |
ANP72333.1 | dnaK-2 | PA27867_1376 | PA27867_3515 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.905 |
ANP72333.1 | groL | PA27867_1376 | PA27867_2789 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.696 |
ANP72333.1 | groS | PA27867_1376 | PA27867_2905 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.708 |
ANP72333.1 | grpE | PA27867_1376 | PA27867_1229 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.741 |
ANP72333.1 | grpE-2 | PA27867_1376 | PA27867_3514 | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...] | 0.741 |
ANP74435.1 | ANP72196.1 | PA27867_3512 | PA27867_1230 | Pfam:pfam13411 MerR HTH family regulatory protein. | Chaperone protein DnaJ; Pfam:pfam00226 DnaJ domain. | 0.734 |
ANP74435.1 | ANP72333.1 | PA27867_3512 | PA27867_1376 | Pfam:pfam13411 MerR HTH family regulatory protein. | AAA family ATPase; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | 0.425 |
ANP74435.1 | ANP74436.1 | PA27867_3512 | PA27867_3513 | Pfam:pfam13411 MerR HTH family regulatory protein. | Molecular chaperone DnaJ; Pfam:pfam00226 DnaJ domain. | 0.937 |