ANP74519.1 protein (Cryobacterium arcticum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ANP74519.1

Hypothetical protein. (144 aa)

Predicted Functional Partners:

ANP74514.1

0.773

ANP74515.1

0.773

ANP74516.1

0.773

ANP74517.1

0.773

ANP74518.1

0.773

ANP74520.1

0.773

ANP74521.1

0.773

ANP74522.1

0.773

ANP74512.1

0.500

ANP74513.1

0.500

Your Current Organism:

Cryobacterium arcticum

NCBI taxonomy Id: 670052
Other names: C. arcticum, Cryobacterium arcticum Bajerski et al. 2011, Cryobacterium sp. SK1, DSM 22823, NCCB 100316, strain SK1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANP74512.1	ANP74513.1	PA27867_3593	PA27867_3594	Hypothetical protein.	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	0.773
ANP74512.1	ANP74514.1	PA27867_3593	PA27867_3595	Hypothetical protein.	Pfam:pfam13392 HNH endonuclease.	0.500
ANP74512.1	ANP74515.1	PA27867_3593	PA27867_3596	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74516.1	PA27867_3593	PA27867_3597	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74517.1	PA27867_3593	PA27867_3598	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74518.1	PA27867_3593	PA27867_3599	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74519.1	PA27867_3593	PA27867_3600	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74520.1	PA27867_3593	PA27867_3601	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74521.1	PA27867_3593	PA27867_3602	Hypothetical protein.	Hypothetical protein.	0.500
ANP74512.1	ANP74522.1	PA27867_3593	PA27867_3603	Hypothetical protein.	Hypothetical protein.	0.500
ANP74513.1	ANP74512.1	PA27867_3594	PA27867_3593	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.773
ANP74513.1	ANP74514.1	PA27867_3594	PA27867_3595	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Pfam:pfam13392 HNH endonuclease.	0.509
ANP74513.1	ANP74515.1	PA27867_3594	PA27867_3596	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74516.1	PA27867_3594	PA27867_3597	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74517.1	PA27867_3594	PA27867_3598	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74518.1	PA27867_3594	PA27867_3599	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74519.1	PA27867_3594	PA27867_3600	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74520.1	PA27867_3594	PA27867_3601	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74521.1	PA27867_3594	PA27867_3602	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500
ANP74513.1	ANP74522.1	PA27867_3594	PA27867_3603	Single-stranded DNA-binding protein; Pfam:pfam00436 Single-strand binding protein family.	Hypothetical protein.	0.500

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.655

expected number of edges:

11

PPI enrichment p-value:

0.0133

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006486

Protein glycosylation

7 of 658

2.01

3.96

6.33e-10

GO:0009938

Negative regulation of gibberellic acid mediated signaling pathway

3 of 18

3.2

3.44

5.64e-07

GO:0006493

Protein O-linked glycosylation

3 of 43

2.82

2.87

5.36e-06

GO:0009910

Negative regulation of flower development

3 of 62

2.66

2.65

1.23e-05

GO:2000377

Regulation of reactive oxygen species metabolic process

3 of 91

2.5

2.37

3.54e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097363

Protein O-GlcNAc transferase activity

7 of 7

3.98

12.16

1.10e-22

GO:0015204

Urea transmembrane transporter activity

3 of 4

3.86

4.11

4.09e-08

GO:0015293

Symporter activity

3 of 419

1.83

1.13

0.0057

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0110165

Cellular anatomical entity

11 of 19699

0.73

0.69

9.29e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43080

Glycosyl transferase family 41, and Unfolded Protein Response (UPR)

6 of 9

3.8

9.51

6.35e-18

CL:43038

Mixed, incl. Ribosomal protein L25/L23, and Protein O-GlcNAc transferase activity

7 of 33

3.31

9.48

3.37e-18

CL:101795

Mixed, incl. Sodium/solute symporter, and Plasma-membrane choline transporter

4 of 11

3.54

5.4

1.71e-10

CL:101797

Mixed, incl. Sodium/solute symporter, and Allantoate deiminase activity

3 of 6

3.68

3.95

7.88e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00514

Other types of O-glycan biosynthesis

7 of 134

2.7

7.83

3.48e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5675482

Regulation of necroptotic cell death

7 of 10

3.83

11.98

2.01e-22

MAP-5213460

RIPK1-mediated regulated necrosis

7 of 10

3.83

11.98

2.01e-22

MAP-5218859

Regulated Necrosis

7 of 19

3.55

11.31

2.26e-21

MAP-5357801

Programmed Cell Death

7 of 172

2.59

7.24

2.66e-15

MAP-5689603

UCH proteinases

7 of 408

2.21

5.43

8.14e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017122

Protein N-acetylglucosaminyltransferase complex

7 of 13

3.71

11.47

1.52e-21

GOCC:0110165

Cellular anatomical entity

7 of 8339

0.9

0.72

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0802

TPR repeat

6 of 350

2.21

4.51

2.35e-10

KW-0677

Repeat

6 of 2899

1.3

1.44

3.24e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13844

Glycosyl transferase family 41

6 of 6

3.98

10.05

7.47e-19

PF00474

Sodium:solute symporter family

3 of 3

3.98

4.21

2.79e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029489

O-GlcNAc transferase, C-terminal

6 of 6

3.98

9.8

2.16e-18

IPR006597

Sel1-like repeat

6 of 20

3.46

8.54

2.68e-16

IPR001440

Tetratricopeptide repeat 1

6 of 76

2.88

6.65

2.71e-13

IPR038377

Sodium/glucose symporter superfamily

3 of 3

3.98

4.17

3.22e-08

IPR037919

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit

3 of 3

3.98

4.17

3.22e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00671

Sel1-like repeats.

6 of 20

3.46

9.0

3.74e-17

SM00028

Tetratricopeptide repeats

6 of 264

2.34

5.01

4.09e-11

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About