SFR34147.1 protein (Litoreibacter janthinus)

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SFR34147.1

LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family. (295 aa)

Predicted Functional Partners:

SFR40450.1

0.716

SFR53042.1

0.714

SFR34932.1

0.694

SFR44420.1

0.679

SFR43117.1

0.656

SFR56652.1

0.651

SFR55810.1

0.623

SFR42546.1

0.599

SFR34497.1

0.548

SFR34153.1

0.543

Your Current Organism:

Litoreibacter janthinus

NCBI taxonomy Id: 670154
Other names: DSM 26921, JCM 16492, KMM 3842, L. janthinus, Litoreibacter janthinus Romanenko et al. 2011, NRIC 0772, alpha proteobacterium KMM 3842

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFR34147.1	SFR34153.1	SAMN04488002_0435	SAMN04488002_0436	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	Hypothetical protein.	0.543
SFR34147.1	SFR34497.1	SAMN04488002_0435	SAMN04488002_0490	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.548
SFR34147.1	SFR34932.1	SAMN04488002_0435	SAMN04488002_0558	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.694
SFR34147.1	SFR40450.1	SAMN04488002_0435	SAMN04488002_1318	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.716
SFR34147.1	SFR42546.1	SAMN04488002_0435	SAMN04488002_1603	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.599
SFR34147.1	SFR43117.1	SAMN04488002_0435	SAMN04488002_1678	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.656
SFR34147.1	SFR44420.1	SAMN04488002_0435	SAMN04488002_1841	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.679
SFR34147.1	SFR53042.1	SAMN04488002_0435	SAMN04488002_2929	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.714
SFR34147.1	SFR55810.1	SAMN04488002_0435	SAMN04488002_3183	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.623
SFR34147.1	SFR56652.1	SAMN04488002_0435	SAMN04488002_3263	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.651
SFR34153.1	SFR34147.1	SAMN04488002_0436	SAMN04488002_0435	Hypothetical protein.	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	0.543
SFR34497.1	SFR34147.1	SAMN04488002_0490	SAMN04488002_0435	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	0.548
SFR34497.1	SFR34932.1	SAMN04488002_0490	SAMN04488002_0558	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.662
SFR34497.1	SFR42546.1	SAMN04488002_0490	SAMN04488002_1603	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.695
SFR34497.1	SFR53042.1	SAMN04488002_0490	SAMN04488002_2929	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.611
SFR34497.1	SFR56652.1	SAMN04488002_0490	SAMN04488002_3263	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.602
SFR34932.1	SFR34147.1	SAMN04488002_0558	SAMN04488002_0435	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	0.694
SFR34932.1	SFR34497.1	SAMN04488002_0558	SAMN04488002_0490	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.662
SFR34932.1	SFR42546.1	SAMN04488002_0558	SAMN04488002_1603	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	0.543
SFR40450.1	SFR34147.1	SAMN04488002_1318	SAMN04488002_0435	DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.	LysR family transcriptional regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.	0.716

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Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.828

expected number of edges:

16

PPI enrichment p-value:

1.58e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 34

1.72

2.59

2.93e-07

GO:0016310

Phosphorylation

10 of 118

1.4

2.45

7.11e-11

GO:0044237

Cellular metabolic process

11 of 1358

0.38

0.31

0.0075

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003988

acetyl-CoA C-acyltransferase activity

4 of 8

2.18

2.63

5.51e-06

GO:0004673

Protein histidine kinase activity

6 of 39

1.66

2.31

1.35e-06

GO:0016740

Transferase activity

10 of 559

0.73

0.68

1.93e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1891

Peptidyl-histidine modification, and HWE histidine kinase

6 of 12

2.18

3.98

3.53e-09

CL:1892

PAS-associated, C-terminal, and GGDEF domain

4 of 7

2.23

2.89

1.80e-06

CL:3102

Mixed, incl. Thiolase, active site, and 3-hydroxyacyl-CoA dehydrogenase, C-terminal

4 of 15

1.9

2.28

1.26e-05

CL:1905

HWE histidine kinase, and Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

2 of 5

2.08

1.18

0.0056

CL:3106

Thiolase, conserved site, and 3-hydroxyacyl-CoA dehydrogenase activity

2 of 6

2.0

1.12

0.0070

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

4 of 22

1.74

1.88

5.83e-05

map00310

Lysine degradation

4 of 28

1.63

1.72

9.26e-05

map00380

Tryptophan metabolism

4 of 29

1.62

1.71

9.26e-05

map02020

Two-component system

10 of 206

1.16

1.65

1.47e-09

map00640

Propanoate metabolism

4 of 39

1.49

0.00019

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

4 of 45

1.43

1.24

0.00086

KW-0012

Acyltransferase

4 of 50

1.38

1.19

0.00096

KW-0418

Kinase

5 of 89

1.23

1.09

0.00067

KW-0808

Transferase

9 of 467

0.76

0.66

0.00021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02803

Thiolase, C-terminal domain

4 of 7

2.23

2.54

1.01e-05

PF00108

Thiolase, N-terminal domain

3 of 5

2.25

1.81

0.00036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020610

Thiolase, active site

4 of 5

2.38

2.61

1.00e-05

IPR020617

Thiolase, C-terminal

4 of 6

2.3

2.58

1.00e-05

IPR020616

Thiolase, N-terminal

4 of 6

2.3

2.58

1.00e-05

IPR002155

Thiolase

4 of 7

2.23

2.55

1.00e-05

IPR016039

Thiolase-like

4 of 13

1.96

2.27

1.74e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00091

PAS domain

4 of 15

1.9

2.36

7.61e-06

SM00388

His Kinase A (phosphoacceptor) domain

5 of 31

1.68

2.19

4.61e-06

SM00387

Histidine kinase-like ATPases

5 of 33

1.66

2.15

4.61e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 10

1.95

1.89

0.00014

SM00448

cheY-homologous receiver domain

4 of 34

1.55

1.61

0.00011

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