node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDW30202.1 | SDW62451.1 | SAMN04488001_0793 | SAMN04488001_1373 | DNA polymerase-3 subunit delta'. | Protein ImuB. | 0.820 |
SDW30202.1 | SDW68736.1 | SAMN04488001_0793 | SAMN04488001_1551 | DNA polymerase-3 subunit delta'. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.997 |
SDW30202.1 | dnaE2 | SAMN04488001_0793 | SAMN04488001_1372 | DNA polymerase-3 subunit delta'. | Error-prone DNA polymerase, DnaE-like; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.989 |
SDW30202.1 | polA | SAMN04488001_0793 | SAMN04488001_2745 | DNA polymerase-3 subunit delta'. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.959 |
SDW30202.1 | recA | SAMN04488001_0793 | SAMN04488001_1013 | DNA polymerase-3 subunit delta'. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.846 |
SDW30202.1 | topA | SAMN04488001_0793 | SAMN04488001_2490 | DNA polymerase-3 subunit delta'. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.887 |
SDW62451.1 | SDW30202.1 | SAMN04488001_1373 | SAMN04488001_0793 | Protein ImuB. | DNA polymerase-3 subunit delta'. | 0.820 |
SDW62451.1 | SDW62477.1 | SAMN04488001_1373 | SAMN04488001_1374 | Protein ImuB. | Protein ImuA. | 0.994 |
SDW62451.1 | SDW68736.1 | SAMN04488001_1373 | SAMN04488001_1551 | Protein ImuB. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.987 |
SDW62451.1 | SDX37430.1 | SAMN04488001_1373 | SAMN04488001_3068 | Protein ImuB. | Cell division protein FtsW; Belongs to the SEDS family. | 0.812 |
SDW62451.1 | dnaE2 | SAMN04488001_1373 | SAMN04488001_1372 | Protein ImuB. | Error-prone DNA polymerase, DnaE-like; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.975 |
SDW62451.1 | lexA | SAMN04488001_1373 | SAMN04488001_1129 | Protein ImuB. | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.902 |
SDW62451.1 | mrdB | SAMN04488001_1373 | SAMN04488001_1405 | Protein ImuB. | Cell elongation-specific peptidoglycan biosynthesis regulator RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.812 |
SDW62451.1 | polA | SAMN04488001_1373 | SAMN04488001_2745 | Protein ImuB. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.880 |
SDW62451.1 | recA | SAMN04488001_1373 | SAMN04488001_1013 | Protein ImuB. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.826 |
SDW62451.1 | topA | SAMN04488001_1373 | SAMN04488001_2490 | Protein ImuB. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.758 |
SDW62477.1 | SDW62451.1 | SAMN04488001_1374 | SAMN04488001_1373 | Protein ImuA. | Protein ImuB. | 0.994 |
SDW62477.1 | dnaE2 | SAMN04488001_1374 | SAMN04488001_1372 | Protein ImuA. | Error-prone DNA polymerase, DnaE-like; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.961 |
SDW62477.1 | recA | SAMN04488001_1374 | SAMN04488001_1013 | Protein ImuA. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.509 |
SDW68736.1 | SDW30202.1 | SAMN04488001_1551 | SAMN04488001_0793 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase-3 subunit delta'. | 0.997 |