node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGK56332.1 | AGK56527.1 | HYPDE_23228 | HYPDE_24208 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | NADH-ubiquinone oxidoreductase chain 49kDa; COG3261 Ni,Fe-hydrogenase III large subunit. | 0.825 |
AGK56332.1 | AGK58246.1 | HYPDE_23228 | HYPDE_32868 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | COG2214 DnaJ-class molecular chaperone. | 0.602 |
AGK56332.1 | dnaK | HYPDE_23228 | HYPDE_40783 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.754 |
AGK56332.1 | groES | HYPDE_23228 | HYPDE_24323 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.910 |
AGK56332.1 | groS | HYPDE_23228 | HYPDE_34703 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.910 |
AGK56332.1 | groS-2 | HYPDE_23228 | HYPDE_36318 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.912 |
AGK56332.1 | grpE | HYPDE_23228 | HYPDE_40788 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.766 |
AGK56332.1 | guaB | HYPDE_23228 | HYPDE_27078 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.673 |
AGK56332.1 | hslU | HYPDE_23228 | HYPDE_40093 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | ATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.621 |
AGK56332.1 | nnrD | HYPDE_23228 | HYPDE_34023 | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | Carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.644 |
AGK56527.1 | AGK56332.1 | HYPDE_24208 | HYPDE_23228 | NADH-ubiquinone oxidoreductase chain 49kDa; COG3261 Ni,Fe-hydrogenase III large subunit. | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | 0.825 |
AGK58246.1 | AGK56332.1 | HYPDE_32868 | HYPDE_23228 | COG2214 DnaJ-class molecular chaperone. | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | 0.602 |
AGK58246.1 | dnaK | HYPDE_32868 | HYPDE_40783 | COG2214 DnaJ-class molecular chaperone. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.982 |
AGK58246.1 | groES | HYPDE_32868 | HYPDE_24323 | COG2214 DnaJ-class molecular chaperone. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.606 |
AGK58246.1 | groS | HYPDE_32868 | HYPDE_34703 | COG2214 DnaJ-class molecular chaperone. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.601 |
AGK58246.1 | groS-2 | HYPDE_32868 | HYPDE_36318 | COG2214 DnaJ-class molecular chaperone. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.604 |
AGK58246.1 | grpE | HYPDE_32868 | HYPDE_40788 | COG2214 DnaJ-class molecular chaperone. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.828 |
AGK58246.1 | hslU | HYPDE_32868 | HYPDE_40093 | COG2214 DnaJ-class molecular chaperone. | ATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.794 |
dnaK | AGK56332.1 | HYPDE_40783 | HYPDE_23228 | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Molecular chaperone GroEL; COG0459 Chaperonin GroEL (HSP60 family). | 0.754 |
dnaK | AGK58246.1 | HYPDE_40783 | HYPDE_32868 | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | COG2214 DnaJ-class molecular chaperone. | 0.982 |