| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGK56466.1 | AGK56480.1 | HYPDE_23903 | HYPDE_23973 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.900 |
| AGK56466.1 | AGK57368.1 | HYPDE_23903 | HYPDE_28443 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.939 |
| AGK56466.1 | AGK57479.1 | HYPDE_23903 | HYPDE_29003 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 0.937 |
| AGK56466.1 | AGK57900.1 | HYPDE_23903 | HYPDE_31128 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | COG1171 Threonine dehydratase. | 0.901 |
| AGK56466.1 | AGK59226.1 | HYPDE_23903 | HYPDE_37773 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-alcohol phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase. | 0.930 |
| AGK56466.1 | AGK59330.1 | HYPDE_23903 | HYPDE_38293 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | HAD-superfamily hydrolase; COG0560 Phosphoserine phosphatase. | 0.903 |
| AGK56466.1 | glyA | HYPDE_23903 | HYPDE_33018 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
| AGK56466.1 | psd | HYPDE_23903 | HYPDE_23898 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.996 |
| AGK56466.1 | trpA | HYPDE_23903 | HYPDE_34563 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
| AGK56466.1 | trpB | HYPDE_23903 | HYPDE_34573 | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| AGK56480.1 | AGK56466.1 | HYPDE_23973 | HYPDE_23903 | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| AGK56480.1 | AGK57900.1 | HYPDE_23973 | HYPDE_31128 | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | COG1171 Threonine dehydratase. | 0.913 |
| AGK56480.1 | AGK59330.1 | HYPDE_23973 | HYPDE_38293 | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | HAD-superfamily hydrolase; COG0560 Phosphoserine phosphatase. | 0.925 |
| AGK56480.1 | glyA | HYPDE_23973 | HYPDE_33018 | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
| AGK56480.1 | trpA | HYPDE_23973 | HYPDE_34563 | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.909 |
| AGK56480.1 | trpB | HYPDE_23973 | HYPDE_34573 | COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.906 |
| AGK57368.1 | AGK56466.1 | HYPDE_28443 | HYPDE_23903 | CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol/serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.939 |
| AGK57368.1 | AGK57479.1 | HYPDE_28443 | HYPDE_29003 | CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 0.928 |
| AGK57368.1 | AGK59226.1 | HYPDE_28443 | HYPDE_37773 | CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-alcohol phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase. | 0.925 |
| AGK57368.1 | psd | HYPDE_28443 | HYPDE_23898 | CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.598 |