STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGK59829.1Hypothetical protein; COG0078 Ornithine carbamoyltransferase. (141 aa)    
Predicted Functional Partners:
AGK59830.1
Glyoxalase/bleomycin resistance protein/dioxygenase; COG0346 Lactoylglutathione lyase and related lyases.
       0.773
AGK59831.1
dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
       0.773
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
       0.697
AGK58345.1
NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes.
  
     0.618
AGK56682.1
Hypothetical protein.
  
     0.617
AGK58243.1
Hypothetical protein.
  
     0.614
AGK58660.1
COG0531 Amino acid transporters.
  
     0.495
AGK56278.1
COG0531 Amino acid transporters.
  
     0.491
AGK57321.1
LuxR family transcriptional regulator; COG2771 DNA-binding HTH domain-containing proteins.
  
     0.490
hrcA
Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
       0.484
Your Current Organism:
Hyphomicrobium denitrificans 1NES1
NCBI taxonomy Id: 670307
Other names: H. denitrificans 1NES1, Hyphomicrobium denitrificans str. 1NES1, Hyphomicrobium denitrificans strain 1NES1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.