STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbiAHydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (443 aa)    
Predicted Functional Partners:
cobQ
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.999
ADR35857.1
cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tra:Trad_0380 cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Cob(I)alamin adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase.
 
 
 0.989
cobT
Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
  
 0.986
cobD
Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
 0.972
ADR36982.1
ATP:cob(I)alamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR002779: IPR017858; KEGG: mrb:Mrub_2492 ATP/cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP/cobalamin adenosyltransferase; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase.
    
 0.918
ADR35855.1
ABC transporter related protein; COGs: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components; InterPro IPR003439: IPR017871: IPR003593; KEGG: tth:TTC0392 iron(III) dicitrate transport ATP-binding protein FecE; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: Iron(III) dicitrate transport ATP-binding protein fecE; PFAM: ABC transporter.
    
 0.883
ADR35861.1
Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: msv:Mesil_3402 hypothetical protein; PFAM: aminotransferase class I and II; SPTR: Putative uncharacterized protein; PFAM: Aminotransferase class I and II.
 
  
 0.861
ADR35853.1
Periplasmic binding protein; COGs: COG0614 ABC-type Fe3+-hydroxamate transport system periplasmic component; InterPro IPR002491; KEGG: ttj:TTHA0746 iron ABC transporter, substrate-binding protein; PFAM: periplasmic binding protein; SPTR: Iron ABC transporter, substrate-binding protein; PFAM: Periplasmic binding protein.
  
  
 0.811
ADR35854.1
COGs: COG0609 ABC-type Fe3+-siderophore transport system permease component; InterPro IPR000522; KEGG: ttj:TTHA0747 iron ABC transporter, permease protein; PFAM: transport system permease protein; SPTR: Transport system permease protein; PFAM: FecCD transport family; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
     
 0.810
cobS
Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.775
Your Current Organism:
Oceanithermus profundus
NCBI taxonomy Id: 670487
Other names: O. profundus DSM 14977, Oceanithermus profundus DSM 14977, Oceanithermus profundus str. DSM 14977, Oceanithermus profundus strain DSM 14977
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.