STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR36526.1COGs: COG4401 Chorismate mutase; InterPro IPR008243; KEGG: ttj:TTHA0868 chorismate mutase; PFAM: Chorismate mutase of the AroH class; SPTR: Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase type I; TIGRFAM: monofunctional chorismate mutase, gram positive type, clade 1. (125 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.947
ADR37653.1
Chorismate mutase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterProIPR010954: IPR006268: IPR020822: IPR006218: IPR 002701; KEGG: ttj:TTHA0388 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: chorismate mutase domain of gram positive AroA protein; phospho-2-dehydro-3-deoxyheptonate aldolase.
    
 0.941
ADR36647.1
COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002912; KEGG: msv:Mesil_1613 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; SPTR: Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; ACT domain.
  
 
  0.925
pheA
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR018528: IPR002912; KEGG: ttj:TTHA1104 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: Prephenate dehydratase; PFAM: Prephenate dehydratase; ACT domain.
    
 0.922
ADR36346.1
CutA1 divalent ion tolerance protein; COGs: COG1324 conserved hypothetical protein involved in tolerance to divalent cations; InterPro IPR004323; KEGG: ttj:TTHA1356 divalent cation tolerance protein (Cut A1); PFAM: CutA1 divalent ion tolerance protein; SPTR: Divalent cation tolerance protein; PFAM: CutA1 divalent ion tolerance protein.
    
   0.911
trpE
Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
    
 0.911
ADR37474.1
COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR017926: IPR006221: IPR000991: IPR006220: IPR 011702: IPR001317; KEGG: mrb:Mrub_2938 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
    
  0.910
mqnA
Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
    
  0.807
ADR36525.1
COGs: COG4475 conserved hypothetical protein; InterPro IPR006340; KEGG: tth:TTC0214 hypothetical protein; PFAM: Conserved hypothetical protein CHP01440; SPTR: UPF0340 protein TT_C0214; PFAM: Protein of unknown function (DUF436); TIGRFAM: conserved hypothetical protein TIGR01440; Belongs to the UPF0340 family.
       0.773
ADR36527.1
Cl- channel voltage-gated family protein; COGs: COG0038 Chloride channel protein EriC; InterPro IPR001807: IPR006037; KEGG: msv:Mesil_1824 Cl-channel voltage-gated family protein; PFAM: Cl- channel voltage-gated family protein; TrkA-C domain protein; SPTR: Cl-channel voltage-gated family protein; PFAM: Voltage gated chloride channel.
       0.773
Your Current Organism:
Oceanithermus profundus
NCBI taxonomy Id: 670487
Other names: O. profundus DSM 14977, Oceanithermus profundus DSM 14977, Oceanithermus profundus str. DSM 14977, Oceanithermus profundus strain DSM 14977
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