STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR36689.1SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395: IPR018039; KEGG: msv:Mesil_1882 SMC domain protein; PFAM: SMC domain protein; SPTR: SMC domain protein; PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: exonuclease SbcC. (897 aa)    
Predicted Functional Partners:
sbcD
Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
 
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.974
ADR36691.1
Hypothetical protein; COGs: COG0433 ATPase; KEGG: ttj:TTHA0522 hypothetical protein; SPTR: Hypothetical conserved protein.
 
     0.906
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.891
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.853
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.816
ADR36692.1
NurA domain; COGs: COG2380 conserved hypothetical protein; InterPro IPR018977; KEGG: ttj:TTHA0521 hypothetical protein; PFAM: NurA domain; SPTR: Putative uncharacterized protein TTHA0521.
       0.794
ADR37182.1
KEGG: msv:Mesil_2972 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 0.697
ADR37292.1
RNA-metabolising metallo-beta-lactamase; COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; InterPro IPR011108; KEGG: mrb:Mrub_1185 beta-lactamase domain-containing protein; PFAM: RNA-metabolising metallo-beta-lactamase; SPTR: Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain.
   
 0.678
ADR36429.1
Mov34/MPN/PAD-1 family protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; KEGG: msv:Mesil_2119 Mov34/MPN/PAD-1 family protein; SPTR: Mov34/MPN/PAD-1 family protein.
    
  0.666
Your Current Organism:
Oceanithermus profundus
NCBI taxonomy Id: 670487
Other names: O. profundus DSM 14977, Oceanithermus profundus DSM 14977, Oceanithermus profundus str. DSM 14977, Oceanithermus profundus strain DSM 14977
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.