node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADR37172.1 | ADR37322.1 | Ocepr_1719 | Ocepr_1870 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.519 |
ADR37172.1 | ADR37323.1 | Ocepr_1719 | Ocepr_1871 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.550 |
ADR37172.1 | ADR37325.1 | Ocepr_1719 | Ocepr_1873 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: ttj:TTHA1749 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (FolK); PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin [...] | 0.596 |
ADR37172.1 | ADR37366.1 | Ocepr_1719 | Ocepr_1914 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.498 |
ADR37172.1 | birA | Ocepr_1719 | Ocepr_2152 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.602 |
ADR37172.1 | folE | Ocepr_1719 | Ocepr_1735 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COGs: COG0302 GTP cyclohydrolase I; InterPro IPR018234: IPR020602: IPR001474; KEGG: ttj:TTHA1878 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. | 0.518 |
ADR37172.1 | ribBA | Ocepr_1719 | Ocepr_1717 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
ADR37320.1 | ADR37321.1 | Ocepr_1868 | Ocepr_1869 | Major facilitator superfamily MFS_1; COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR005829: IPR011701; KEGG: mrb:Mrub_2955 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily. | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | 0.721 |
ADR37320.1 | ADR37322.1 | Ocepr_1868 | Ocepr_1870 | Major facilitator superfamily MFS_1; COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR005829: IPR011701; KEGG: mrb:Mrub_2955 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.542 |
ADR37320.1 | ADR37323.1 | Ocepr_1868 | Ocepr_1871 | Major facilitator superfamily MFS_1; COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR005829: IPR011701; KEGG: mrb:Mrub_2955 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.510 |
ADR37321.1 | ADR37320.1 | Ocepr_1869 | Ocepr_1868 | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | Major facilitator superfamily MFS_1; COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR005829: IPR011701; KEGG: mrb:Mrub_2955 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily. | 0.721 |
ADR37321.1 | ADR37322.1 | Ocepr_1869 | Ocepr_1870 | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.554 |
ADR37321.1 | ADR37323.1 | Ocepr_1869 | Ocepr_1871 | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.554 |
ADR37321.1 | ADR37324.1 | Ocepr_1869 | Ocepr_1872 | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | Plasma-membrane proton-efflux P-type ATPase; COGs: COG0474 Cation transport ATPase; InterProIPR018303: IPR006534: IPR001757: IPR004014: IPR 008250: IPR005834; KEGG: nis:NIS_0930 H+-transporting P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; PRIAM: Proton-exporting ATPase; SPTR: H+-transporting P-type ATPase; TIGRFAM: plasma-membrane proton-efflux P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; haloacid dehalogenase-like hydrolase; Cat [...] | 0.524 |
ADR37321.1 | ADR37325.1 | Ocepr_1869 | Ocepr_1873 | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: ttj:TTHA1749 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (FolK); PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin [...] | 0.443 |
ADR37322.1 | ADR37172.1 | Ocepr_1870 | Ocepr_1719 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.519 |
ADR37322.1 | ADR37320.1 | Ocepr_1870 | Ocepr_1868 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Major facilitator superfamily MFS_1; COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR005829: IPR011701; KEGG: mrb:Mrub_2955 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily. | 0.542 |
ADR37322.1 | ADR37321.1 | Ocepr_1870 | Ocepr_1869 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | UspA domain-containing protein; InterPro IPR006016; KEGG: ttj:TTHA0192 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Universal stress protein family; PFAM: Universal stress protein family. | 0.554 |
ADR37322.1 | ADR37323.1 | Ocepr_1870 | Ocepr_1871 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.999 |
ADR37322.1 | ADR37324.1 | Ocepr_1870 | Ocepr_1872 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Plasma-membrane proton-efflux P-type ATPase; COGs: COG0474 Cation transport ATPase; InterProIPR018303: IPR006534: IPR001757: IPR004014: IPR 008250: IPR005834; KEGG: nis:NIS_0930 H+-transporting P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; PRIAM: Proton-exporting ATPase; SPTR: H+-transporting P-type ATPase; TIGRFAM: plasma-membrane proton-efflux P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; haloacid dehalogenase-like hydrolase; Cat [...] | 0.608 |