STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR37452.1COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: sat:SYN_01257 serine acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: Serine acetyltransferase; TIGRFAM: serine O-acetyltransferase. (280 aa)    
Predicted Functional Partners:
ADR36058.1
COGs: COG0031 Cysteine synthase; InterProIPR005856: IPR005859: IPR001926: IPR000634: IPR 001216; KEGG: msv:Mesil_1087 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.997
cysS
COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR002308: IPR015803: IPR015273; KEGG: msv:Mesil_1698 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.985
ADR36505.1
COGs: COG1760 L-serine deaminase; InterPro IPR004642: IPR005130; KEGG: ttj:TTHA1029 L-serine dehydratase, alpha subunit; PFAM: serine dehydratase alpha chain; PRIAM: L-serine ammonia-lyase; SPTR: L-serine dehydratase, alpha subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: Serine dehydratase alpha chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit.
     
 0.909
ADR36661.1
COGs: COG1760 L-serine deaminase; InterPro IPR004643: IPR005131: IPR004294: IPR002912; KEGG: ttj:TTHA0739 L-serine dehydratase, beta subunit; PFAM: serine dehydratase beta chain; Carotenoid oxygenase; amino acid-binding ACT domain protein; PRIAM: L-serine ammonia-lyase; SPTR: L-serine dehydratase, beta subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: ACT domain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit.
     
 0.909
ADR36774.1
COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106: IPR001342; KEGG: msv:Mesil_1361 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; PRIAM: Homoserine dehydrogenase; SPTR: Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase.
  
  
 0.862
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.832
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
 0.831
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.815
ADR35848.1
Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG1171 Threonine dehydratase; InterPro IPR001926; KEGG: tro:trd_0006 threonine ammonia-lyase, biosynthetic; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Threonine ammonia-lyase, biosynthetic; PFAM: Pyridoxal-phosphate dependent enzyme.
    
 0.814
trpB
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.814
Your Current Organism:
Oceanithermus profundus
NCBI taxonomy Id: 670487
Other names: O. profundus DSM 14977, Oceanithermus profundus DSM 14977, Oceanithermus profundus str. DSM 14977, Oceanithermus profundus strain DSM 14977
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