STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ogtO-6-methylguanine DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (151 aa)    
Predicted Functional Partners:
thrS
PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.863
EHP68272.1
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; PFAM: Glycosyltransferase family 28 C-terminal domain; Oligosaccharide biosynthesis protein Alg14 like.
     
 0.738
EHP68585.1
Putative endoIII-related endonuclease; PFAM: HhH-GPD superfamily base excision DNA repair protein.
 
   
 0.682
EHP68271.1
Putative endonuclease III-like protein; PFAM: HhH-GPD superfamily base excision DNA repair protein.
     
 0.634
EHP70756.1
Endonuclease IV; PFAM: Xylose isomerase-like TIM barrel.
 
   
 0.574
EHP68817.1
DNA helicase, Rad3; PFAM: DEAD_2.
     
 0.568
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
   
 
 0.563
EHP69214.1
PFAM: Universal stress protein family.
  
    0.557
EHP68278.1
PFAM: Universal stress protein family.
  
    0.557
EHP68338.1
PFAM: Universal stress protein family.
  
    0.557
Your Current Organism:
Metallosphaera yellowstonensis
NCBI taxonomy Id: 671065
Other names: M. yellowstonensis MK1, Metallosphaera sp. MK1, Metallosphaera yellowstonensis MK1, Metallosphaera yellowstonensis str. MK1, Metallosphaera yellowstonensis strain MK1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.