node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHP68771.1 | EHP69432.1 | MetMK1DRAFT_00032160 | MetMK1DRAFT_00021880 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 0.818 |
EHP68771.1 | EHP69514.1 | MetMK1DRAFT_00032160 | MetMK1DRAFT_00022800 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | Threonine dehydratase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. | 0.772 |
EHP68771.1 | EHP70239.1 | MetMK1DRAFT_00032160 | MetMK1DRAFT_00007410 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. | 0.462 |
EHP68771.1 | EHP71090.1 | MetMK1DRAFT_00032160 | MetMK1DRAFT_00015940 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. | 0.453 |
EHP68771.1 | ilvC | MetMK1DRAFT_00032160 | MetMK1DRAFT_00032180 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.994 |
EHP68771.1 | ilvD | MetMK1DRAFT_00032160 | MetMK1DRAFT_00012360 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.942 |
EHP68771.1 | leuC | MetMK1DRAFT_00032160 | MetMK1DRAFT_00010140 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.721 |
EHP68771.1 | leuD | MetMK1DRAFT_00032160 | MetMK1DRAFT_00010150 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.752 |
EHP69299.1 | EHP69432.1 | MetMK1DRAFT_00020480 | MetMK1DRAFT_00021880 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 0.723 |
EHP69299.1 | EHP69514.1 | MetMK1DRAFT_00020480 | MetMK1DRAFT_00022800 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | Threonine dehydratase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. | 0.669 |
EHP69299.1 | EHP70239.1 | MetMK1DRAFT_00020480 | MetMK1DRAFT_00007410 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. | 0.711 |
EHP69299.1 | EHP71090.1 | MetMK1DRAFT_00020480 | MetMK1DRAFT_00015940 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. | 0.706 |
EHP69299.1 | ilvC | MetMK1DRAFT_00020480 | MetMK1DRAFT_00032180 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.881 |
EHP69299.1 | ilvD | MetMK1DRAFT_00020480 | MetMK1DRAFT_00012360 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.835 |
EHP69299.1 | leuC | MetMK1DRAFT_00020480 | MetMK1DRAFT_00010140 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.708 |
EHP69299.1 | leuD | MetMK1DRAFT_00020480 | MetMK1DRAFT_00010150 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.742 |
EHP69432.1 | EHP68771.1 | MetMK1DRAFT_00021880 | MetMK1DRAFT_00032160 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. | 0.818 |
EHP69432.1 | EHP69299.1 | MetMK1DRAFT_00021880 | MetMK1DRAFT_00020480 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. | 0.723 |
EHP69432.1 | EHP69514.1 | MetMK1DRAFT_00021880 | MetMK1DRAFT_00022800 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Threonine dehydratase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. | 0.954 |
EHP69432.1 | EHP70226.1 | MetMK1DRAFT_00021880 | MetMK1DRAFT_00007280 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. | 0.818 |