node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUR31339.1 | hisA | PL9214290930 | PL9214290604 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | 0.910 |
CUR31339.1 | hisB | PL9214290930 | PL9214290264 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.971 |
CUR31339.1 | hisD | PL9214290930 | PL9214291221 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.975 |
CUR31339.1 | hisF | PL9214290930 | PL9214290457 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.964 |
CUR31339.1 | hisG | PL9214290930 | PL9214500453 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.919 |
CUR31339.1 | hisH | PL9214290930 | PL921480110 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.972 |
CUR31339.1 | hisI | PL9214290930 | PL9214500566 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.897 |
CUR31339.1 | hisI-2 | PL9214290930 | PL9214520279 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Histidine biosynthesis bifunctional protein HisIE (Includes: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase). | 0.998 |
CUR31339.1 | hisZ | PL9214290930 | PL9214650471 | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.831 |
hisA | CUR31339.1 | PL9214290604 | PL9214290930 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.910 |
hisA | hisB | PL9214290604 | PL9214290264 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.995 |
hisA | hisD | PL9214290604 | PL9214291221 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisF | PL9214290604 | PL9214290457 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.988 |
hisA | hisG | PL9214290604 | PL9214500453 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.995 |
hisA | hisH | PL9214290604 | PL921480110 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.996 |
hisA | hisI | PL9214290604 | PL9214500566 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.998 |
hisA | hisI-2 | PL9214290604 | PL9214520279 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | Histidine biosynthesis bifunctional protein HisIE (Includes: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase). | 0.999 |
hisA | hisZ | PL9214290604 | PL9214650471 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.947 |
hisB | CUR31339.1 | PL9214290264 | PL9214290930 | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative histidinol-phosphate/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.971 |
hisB | hisA | PL9214290264 | PL9214290604 | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. | 0.995 |