Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
pyrCDihydroorotase (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (446 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase (catalytic subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
carA
Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family.
  
 0.998
carB
Carbamoyl phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family.
 
 0.998
pyrD
Dihydroorotate dehydrogenase (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD); Catalyzes the conversion of dihydroorotate to orotate.
 
 0.998
pyrK
Putative Dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 
 
 0.995
pyrR
Bifunctional protein pyrR [Includes: Pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
 
 0.980
argF
Ornithine carbamoyltransferase (OTCase); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
 
  
 0.927
pyrF-2
Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the OMP decarboxylase family.
 
  
 0.888
pyrF
Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.872
pyrE
Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.871
Your Current Organism:
Methylomirabilis oxyfera
NCBI taxonomy Id: 671143
Other names: C. Methylomirabilis oxyfera, Candidatus Methylomirabilis oxyfera
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