STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoPutative endonuclease 4 (Endonuclease IV) (Endodeoxyribonuclease IV); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (296 aa)    
Predicted Functional Partners:
DAMO_2525
Homologs of previously reported genes of unknown function.
       0.678
DAMO_2528
Putative Cell division protein FtsX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
 
     0.524
DAMO_1678
Homologs of previously reported genes of unknown function.
  
 
 0.504
nth
Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.504
DAMO_3042
Homologs of previously reported genes of unknown function.
  
 
 0.504
DAMO_3151
Putative Endonuclease III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 
 0.504
DAMO_0395
Superoxide dismutase.
  
  
 0.492
ftsE
Cell division ABC transpoter (ATP-binding protein); Part of the ABC transporter FtsEX involved in cellular division.
       0.447
polA
DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.440
DAMO_1157
DNA polymerase III, delta prime subunit.
 
     0.430
Your Current Organism:
Methylomirabilis oxyfera
NCBI taxonomy Id: 671143
Other names: C. Methylomirabilis oxyfera, Candidatus Methylomirabilis oxyfera
Server load: low (22%) [HD]