STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypEHydrogenase expression/formation protein HypE; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)    
Predicted Functional Partners:
hypD
Hydrogenase formation protein HupD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family.
 
 
 0.999
hypC
Hydrogenase assembly protein HupF; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.998
hypF
Hypothetical protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 0.997
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.941
hypB
Hydrogenase nickel incorporation protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.939
AMG31859.1
Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.926
hydA
NADH:ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.920
hycI
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
   
 0.847
hoxH
NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.808
hupR1_3
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.720
Your Current Organism:
Grimontia hollisae
NCBI taxonomy Id: 673
Other names: ATCC 33564, CAIM 625, CCUG 13625, CDC 0075-80, CIP 101886, DSM 15132, G. hollisae, IMET 12291, LMG 17719, LMG:17719, NCTC 11640, Special Bacteriology group EF-13, Vibrio hollisae
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