STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TdcB_1Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.758
IlvH
Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.723
GltB
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.710
KUN68661.1
Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
  
 0.687
KUN65569.1
Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.686
ilvD
Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
  
 0.677
AraC_2
Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
  
 0.669
IlvE_1
Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.607
Hom
Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.597
leuD
Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.548
Your Current Organism:
Streptomyces griseorubiginosus
NCBI taxonomy Id: 67304
Other names: ATCC 23627, ATCC 23946 [[Streptomyces phaeopurpureus]], ATCC 23947 [[Streptomyces phaeoviridis]], ATCC 25459, Actinomyces griseorubiginosus, BCRC 12124, BCRC 13754 [[Streptomyces phaeopurpureus]], CBS 692.69, CBS 930.68 [[Streptomyces phaeopurpureus]], CCRC 12124, CCRC 13754 [[Streptomyces phaeopurpureus]], CCRC:12124, CCRC:13754 [[Streptomyces phaeopurpureus]], DSM 40125 [[Streptomyces phaeopurpureus]], DSM 40469, HAMBI 950 [[Streptomyces phaeopurpureus]], IFO 12899 [[Streptomyces phaeopurpureus]], IFO 12900 [[Streptomyces phaeoviridis]], IFO 13047, IFO 3930 [[Streptomyces phaeopurpureus]], INA 7712, ISP 5125 [[Streptomyces phaeopurpureus]], ISP 5469, JCM 4101 [[Streptomyces phaeopurpureus]], JCM 4481, JCM 4660 [[Streptomyces phaeopurpureus]], JCM 4661 [[Streptomyces phaeoviridis]], KCTC 9764 [[Streptomyces phaeopurpureus]], LMG 19941, LMG:19941, NBRC 12899 [[Streptomyces phaeopurpureus]], NBRC 12900 [[Streptomyces phaeoviridis]], NBRC 13047, NBRC 3930 [[Streptomyces phaeopurpureus]], NCIMB 9832 [[Streptomyces phaeoviridis]], NRRL B-12384, NRRL B-2258 [[Streptomyces phaeoviridis]], NRRL B-2260 [[Streptomyces phaeopurpureus]], NRRL-ISP 5125 [[Streptomyces phaeopurpureus]], NRRL-ISP 5469, NRRL:B:2258 [[Streptomyces phaeoviridis]], S. griseorubiginosus, Streptomyces griseirubiginosus, Streptomyces phaeopurpureus, Streptomyces phaeoviridis
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