Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ureDUrease accessory protein ureD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. (259 aa)    
Predicted Functional Partners:
ureF
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.997
UreA_1
Urease subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.989
ureB
Urease subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease beta subunit family.
 
 
 0.986
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
 
 0.984
ureA
Urease subunit gamma; UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family.
 
 
 0.977
ureC
Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.914
UreC_1
Urease subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.764
KUN64293.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.681
LptB_4
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family.
 
   
 0.678
YfiR_1
TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.665
Your Current Organism:
Streptomyces griseorubiginosus
NCBI taxonomy Id: 67304
Other names: ATCC 23627, ATCC 23946 [[Streptomyces phaeopurpureus]], ATCC 23947 [[Streptomyces phaeoviridis]], ATCC 25459, Actinomyces griseorubiginosus, BCRC 12124, BCRC 13754 [[Streptomyces phaeopurpureus]], CBS 692.69, CBS 930.68 [[Streptomyces phaeopurpureus]], CCRC 12124, CCRC 13754 [[Streptomyces phaeopurpureus]], CCRC:12124, CCRC:13754 [[Streptomyces phaeopurpureus]], DSM 40125 [[Streptomyces phaeopurpureus]], DSM 40469, HAMBI 950 [[Streptomyces phaeopurpureus]], IFO 12899 [[Streptomyces phaeopurpureus]], IFO 12900 [[Streptomyces phaeoviridis]], IFO 13047, IFO 3930 [[Streptomyces phaeopurpureus]], INA 7712, ISP 5125 [[Streptomyces phaeopurpureus]], ISP 5469, JCM 4101 [[Streptomyces phaeopurpureus]], JCM 4481, JCM 4660 [[Streptomyces phaeopurpureus]], JCM 4661 [[Streptomyces phaeoviridis]], KCTC 9764 [[Streptomyces phaeopurpureus]], LMG 19941, LMG:19941, NBRC 12899 [[Streptomyces phaeopurpureus]], NBRC 12900 [[Streptomyces phaeoviridis]], NBRC 13047, NBRC 3930 [[Streptomyces phaeopurpureus]], NCIMB 9832 [[Streptomyces phaeoviridis]], NRRL B-12384, NRRL B-2258 [[Streptomyces phaeoviridis]], NRRL B-2260 [[Streptomyces phaeopurpureus]], NRRL-ISP 5125 [[Streptomyces phaeopurpureus]], NRRL-ISP 5469, NRRL:B:2258 [[Streptomyces phaeoviridis]], S. griseorubiginosus, Streptomyces griseirubiginosus, Streptomyces phaeopurpureus, Streptomyces phaeoviridis
Server load: low (36%) [HD]