STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KUN63791.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
       0.871
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.865
hisE
phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.811
KUN63795.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.808
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
   0.784
RibE
Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.754
rpsM_2
30S ribosomal protein S13; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  0.736
KUN68424.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.615
RibD2_2
5-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.603
whiB-3
DNA-binding protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.600
Your Current Organism:
Streptomyces griseorubiginosus
NCBI taxonomy Id: 67304
Other names: ATCC 23627, ATCC 23946 [[Streptomyces phaeopurpureus]], ATCC 23947 [[Streptomyces phaeoviridis]], ATCC 25459, Actinomyces griseorubiginosus, BCRC 12124, BCRC 13754 [[Streptomyces phaeopurpureus]], CBS 692.69, CBS 930.68 [[Streptomyces phaeopurpureus]], CCRC 12124, CCRC 13754 [[Streptomyces phaeopurpureus]], CCRC:12124, CCRC:13754 [[Streptomyces phaeopurpureus]], DSM 40125 [[Streptomyces phaeopurpureus]], DSM 40469, HAMBI 950 [[Streptomyces phaeopurpureus]], IFO 12899 [[Streptomyces phaeopurpureus]], IFO 12900 [[Streptomyces phaeoviridis]], IFO 13047, IFO 3930 [[Streptomyces phaeopurpureus]], INA 7712, ISP 5125 [[Streptomyces phaeopurpureus]], ISP 5469, JCM 4101 [[Streptomyces phaeopurpureus]], JCM 4481, JCM 4660 [[Streptomyces phaeopurpureus]], JCM 4661 [[Streptomyces phaeoviridis]], KCTC 9764 [[Streptomyces phaeopurpureus]], LMG 19941, LMG:19941, NBRC 12899 [[Streptomyces phaeopurpureus]], NBRC 12900 [[Streptomyces phaeoviridis]], NBRC 13047, NBRC 3930 [[Streptomyces phaeopurpureus]], NCIMB 9832 [[Streptomyces phaeoviridis]], NRRL B-12384, NRRL B-2258 [[Streptomyces phaeoviridis]], NRRL B-2260 [[Streptomyces phaeopurpureus]], NRRL-ISP 5125 [[Streptomyces phaeopurpureus]], NRRL-ISP 5469, NRRL:B:2258 [[Streptomyces phaeoviridis]], S. griseorubiginosus, Streptomyces griseirubiginosus, Streptomyces phaeopurpureus, Streptomyces phaeoviridis
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