Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SEB31581.1Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. (303 aa)    
Predicted Functional Partners:
egtD
L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
 
 
 0.861
SEB31575.1
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase.
 
     0.819
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
  
 
 0.760
SEB91525.1
Hypothetical protein.
  
   0.748
SEB97122.1
Glutamine amidotransferase.
  
 
 0.712
egtC
Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
  
 
 0.712
SEB83387.1
Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
   
 
  0.704
SEB31924.1
Hypothetical protein.
 
  
  0.701
ribBA
GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.678
SED79075.1
Amino acid adenylation domain-containing protein.
  
  
 0.581
Your Current Organism:
Streptomyces misionensis
NCBI taxonomy Id: 67331
Other names: ATCC 14991, ATCC 25475, BCRC 12094, CBS 885.69, CCRC 12094, CCRC:12094, DSM 40306, IFO 13063, ISP 5306, JCM 4497, NBRC 13063, NRRL B-3230, NRRL-ISP 5306, S. misionensis, Streptomyces misionesensis, VKM Ac-626
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