Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SEC42807.1uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (410 aa)    
Predicted Functional Partners:
SEC56109.1
Sirohydrochlorin cobaltochelatase.
 
 0.998
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.997
hemC-2
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.997
SED85312.1
Sulfite reductase (ferredoxin); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
 
 0.996
SED32165.1
uroporphyrinogen-III synthase.
 
 
0.995
SEC56019.1
Cobalt-precorrin 5A hydrolase / precorrin-3B C17-methyltransferase.
 
 
 0.994
SED95850.1
Sirohydrochlorin ferrochelatase.
 
 0.994
SED85039.1
Sirohydrochlorin ferrochelatase.
 
 
 0.993
SED32698.1
Porphobilinogen synthase; Belongs to the ALAD family.
 
 
 0.989
SEC42882.1
precorrin-6Y C5,15-methyltransferase (decarboxylating).
 
 
 0.987
Your Current Organism:
Streptomyces misionensis
NCBI taxonomy Id: 67331
Other names: ATCC 14991, ATCC 25475, BCRC 12094, CBS 885.69, CCRC 12094, CCRC:12094, DSM 40306, IFO 13063, ISP 5306, JCM 4497, NBRC 13063, NRRL B-3230, NRRL-ISP 5306, S. misionensis, Streptomyces misionesensis, VKM Ac-626
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