node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SAMN05216505_10189 | SAMN05216505_104228 | SAMN05216505_10189 | SAMN05216505_104228 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PAS domain S-box-containing protein. | 0.517 |
SAMN05216505_10189 | SAMN05216505_10435 | SAMN05216505_10189 | SAMN05216505_10435 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.897 |
SAMN05216505_10189 | SAMN05216505_104415 | SAMN05216505_10189 | SAMN05216505_104415 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | XTP/dITP diphosphohydrolase. | 0.916 |
SAMN05216505_10189 | SAMN05216505_109156 | SAMN05216505_10189 | SAMN05216505_109156 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.906 |
SAMN05216505_10189 | SAMN05216505_11799 | SAMN05216505_10189 | SAMN05216505_11799 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.463 |
SAMN05216505_10189 | guaA | SAMN05216505_10189 | SAMN05216505_103354 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.977 |
SAMN05216505_10189 | ribBA | SAMN05216505_10189 | SAMN05216505_11743 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.636 |
SAMN05216505_104228 | SAMN05216505_10189 | SAMN05216505_104228 | SAMN05216505_10189 | PAS domain S-box-containing protein. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.517 |
SAMN05216505_104228 | SAMN05216505_104415 | SAMN05216505_104228 | SAMN05216505_104415 | PAS domain S-box-containing protein. | XTP/dITP diphosphohydrolase. | 0.880 |
SAMN05216505_104228 | SAMN05216505_1085 | SAMN05216505_104228 | SAMN05216505_1085 | PAS domain S-box-containing protein. | Histidine kinase. | 0.999 |
SAMN05216505_104228 | SAMN05216505_109156 | SAMN05216505_104228 | SAMN05216505_109156 | PAS domain S-box-containing protein. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.429 |
SAMN05216505_104228 | SAMN05216505_11229 | SAMN05216505_104228 | SAMN05216505_11229 | PAS domain S-box-containing protein. | PAS domain S-box-containing protein. | 0.999 |
SAMN05216505_104228 | SAMN05216505_11799 | SAMN05216505_104228 | SAMN05216505_11799 | PAS domain S-box-containing protein. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.863 |
SAMN05216505_104228 | guaA | SAMN05216505_104228 | SAMN05216505_103354 | PAS domain S-box-containing protein. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.781 |
SAMN05216505_104228 | ribBA | SAMN05216505_104228 | SAMN05216505_11743 | PAS domain S-box-containing protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.920 |
SAMN05216505_10435 | SAMN05216505_10189 | SAMN05216505_10435 | SAMN05216505_10189 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.897 |
SAMN05216505_10435 | SAMN05216505_104415 | SAMN05216505_10435 | SAMN05216505_104415 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | XTP/dITP diphosphohydrolase. | 0.898 |
SAMN05216505_10435 | SAMN05216505_109156 | SAMN05216505_10435 | SAMN05216505_109156 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.900 |
SAMN05216505_10435 | guaA | SAMN05216505_10435 | SAMN05216505_103354 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.915 |
SAMN05216505_104415 | SAMN05216505_10189 | SAMN05216505_104415 | SAMN05216505_10189 | XTP/dITP diphosphohydrolase. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.916 |