STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)    
Predicted Functional Partners:
SAMN05216505_107259
23S rRNA (Cytidine1920-2'-O)/16S rRNA (Cytidine1409-2'-O)-methyltransferase.
  
  
 0.950
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.936
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.930
nadK-2
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 
0.922
cobB-2
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily.
    
 0.909
nadE-2
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
    
 0.908
SAMN05216505_107260
Uncharacterized protein.
       0.877
SAMN05216505_107257
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
 
  
 0.874
SAMN05216505_107261
SCP-2 sterol transfer family protein.
       0.796
SAMN05216505_107256
Glycosyltransferase involved in cell wall bisynthesis.
       0.678
Your Current Organism:
Streptomyces prasinopilosus
NCBI taxonomy Id: 67344
Other names: ATCC 19799, BCRC 13678, CBS 551.68, CCRC 13678, CCRC:13678, CGMCC 4.3504 [[Streptomyces emeiensis]], DSM 40098, DSM 41884 [[Streptomyces emeiensis]], IFO 12809, ISP 5098, JCM 15479 [[Streptomyces emeiensis]], JCM 4207, JCM 4404, LMG 19345, LMG:19345, NBRC 12809, NCIMB 9842, NRRL B-2711, NRRL-ISP 5098, S. prasinopilosus, Streptomyces emeiensis, Streptomyces emeiensis Sun et al. 2007, Streptomyces sp. 034776, UNIQEM 185, strain 4776 [[Streptomyces emeiensis]]
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