STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (476 aa)    
Predicted Functional Partners:
SEO77951.1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.982
SEO77191.1
Succinate dehydrogenase subunit A.
 
 0.981
SEO69000.1
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.975
mqo
Malate dehydrogenase (quinone).
    
 0.973
SEO77016.1
Succinate dehydrogenase subunit A.
 
 0.952
SEO77199.1
Succinate dehydrogenase subunit B.
  
 0.947
SEO77025.1
Succinate dehydrogenase subunit B.
  
 0.937
SEO91667.1
2-oxoglutarate dehydrogenase E1 component.
 
 0.933
SEO69031.1
Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
 0.913
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.906
Your Current Organism:
Blastococcus endophyticus
NCBI taxonomy Id: 673521
Other names: B. endophyticus, Blastococcus endophyticus Zhu et al. 2013 emend. Hezbri et al. 2016, Blastococcus sp. YIM 68236, CCTCC AA 209045, DSM 45413, KCTC 19998, YIM 68236
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