node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEO85056.1 | SEO90086.1 | SAMN05660991_02013 | SAMN05660991_02241 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-lyase. | 0.977 |
SEO85056.1 | SEO90637.1 | SAMN05660991_02013 | SAMN05660991_02287 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin-independent synthase, Catalytic domain. | 0.971 |
SEO85056.1 | SEO92272.1 | SAMN05660991_02013 | SAMN05660991_02410 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-synthase. | 0.966 |
SEO85056.1 | SEO92290.1 | SAMN05660991_02013 | SAMN05660991_02411 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-lyase. | 0.977 |
SEO85056.1 | SEO97930.1 | SAMN05660991_02013 | SAMN05660991_02675 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
SEO85056.1 | SEP17194.1 | SAMN05660991_02013 | SAMN05660991_03686 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase. | 0.965 |
SEO85056.1 | folD | SAMN05660991_02013 | SAMN05660991_01284 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.888 |
SEO85056.1 | glyA | SAMN05660991_02013 | SAMN05660991_02683 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
SEO85056.1 | metK | SAMN05660991_02013 | SAMN05660991_02495 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.984 |
SEO85056.1 | thyA | SAMN05660991_02013 | SAMN05660991_03499 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.754 |
SEO90086.1 | SEO85056.1 | SAMN05660991_02241 | SAMN05660991_02013 | Cystathionine gamma-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.977 |
SEO90086.1 | SEO90637.1 | SAMN05660991_02241 | SAMN05660991_02287 | Cystathionine gamma-lyase. | Cobalamin-independent synthase, Catalytic domain. | 0.759 |
SEO90086.1 | SEO92272.1 | SAMN05660991_02241 | SAMN05660991_02410 | Cystathionine gamma-lyase. | Cystathionine beta-synthase. | 0.996 |
SEO90086.1 | SEO92290.1 | SAMN05660991_02241 | SAMN05660991_02411 | Cystathionine gamma-lyase. | Cystathionine gamma-lyase. | 0.882 |
SEO90086.1 | SEO97930.1 | SAMN05660991_02241 | SAMN05660991_02675 | Cystathionine gamma-lyase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.790 |
SEO90086.1 | glyA | SAMN05660991_02241 | SAMN05660991_02683 | Cystathionine gamma-lyase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.471 |
SEO90086.1 | metK | SAMN05660991_02241 | SAMN05660991_02495 | Cystathionine gamma-lyase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.800 |
SEO90637.1 | SEO85056.1 | SAMN05660991_02287 | SAMN05660991_02013 | Cobalamin-independent synthase, Catalytic domain. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
SEO90637.1 | SEO90086.1 | SAMN05660991_02287 | SAMN05660991_02241 | Cobalamin-independent synthase, Catalytic domain. | Cystathionine gamma-lyase. | 0.759 |
SEO90637.1 | SEO92272.1 | SAMN05660991_02287 | SAMN05660991_02410 | Cobalamin-independent synthase, Catalytic domain. | Cystathionine beta-synthase. | 0.856 |