STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)    
Predicted Functional Partners:
mdh
Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.990
SPAR_08571
Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.987
sdhA
Unannotated protein.
 
 0.974
SPAR_41449
Unannotated protein.
   
 
 0.973
sdhA-2
Unannotated protein.
 0.973
sucC-2
Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.972
sdhB
Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.971
SPAR_37945
Unannotated protein.
  
 0.966
SPAR_42114
Unannotated protein; Belongs to the citrate synthase family.
   
 0.966
SPAR_08366
Unannotated protein.
  
 0.966
Your Current Organism:
Streptomyces sparsogenes
NCBI taxonomy Id: 67365
Other names: ATCC 25498, BCRC 12085, CBS 672.69, CBS 958.69, CCRC 12085, CCRC:12085, DSM 40356, IFO 13086, ISP 5356, JCM 4517, LMG 5985, LMG:5985, NBRC 13086, NCIMB 9449, NRRL 2940, NRRL-ISP 5356, S. sparsogenes, Streptomyces sparsigenes, Streptomyces sparsogenes var. sparsognes
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