| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VM_08310 | VM_08320 | VM_08310 | VM_08320 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.404 |
| VM_08310 | pabB | VM_08310 | VM_08315 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Aminodeoxychorismate synthase, component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.668 |
| VM_08320 | VM_08310 | VM_08320 | VM_08310 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.404 |
| VM_08320 | VM_08325 | VM_08320 | VM_08325 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Septum formation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.472 |
| VM_08320 | birA | VM_08320 | VM_14040 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.536 |
| VM_08320 | dapF | VM_08320 | VM_00585 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.445 |
| VM_08320 | nnrD | VM_08320 | VM_17825 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | 0.744 |
| VM_08320 | nudC | VM_08320 | VM_13960 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | NADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.404 |
| VM_08320 | pabB | VM_08320 | VM_08315 | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminodeoxychorismate synthase, component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.532 |
| VM_08325 | VM_08320 | VM_08325 | VM_08320 | Septum formation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.472 |
| birA | VM_08320 | VM_14040 | VM_08320 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.536 |
| birA | dapF | VM_14040 | VM_00585 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.485 |
| birA | nnrD | VM_14040 | VM_17825 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | 0.538 |
| dapF | VM_08320 | VM_00585 | VM_08320 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.445 |
| dapF | birA | VM_00585 | VM_14040 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.485 |
| nnrD | VM_08320 | VM_17825 | VM_08320 | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.744 |
| nnrD | birA | VM_17825 | VM_14040 | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.538 |
| nudC | VM_08320 | VM_13960 | VM_08320 | NADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily. | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.404 |
| pabB | VM_08310 | VM_08315 | VM_08310 | Aminodeoxychorismate synthase, component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.668 |
| pabB | VM_08320 | VM_08315 | VM_08320 | Aminodeoxychorismate synthase, component I; Derived by automated computational analysis using gene prediction method: Protein Homology. | Coenzyme A pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.532 |