| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VM_12185 | dksA | VM_12185 | VM_12205 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 0.632 |
| VM_12185 | folK | VM_12185 | VM_12220 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.591 |
| VM_12185 | gluQ | VM_12185 | VM_12210 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | tRNA glutamyl-Q synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.669 |
| VM_12185 | hrpB | VM_12185 | VM_12195 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.739 |
| VM_12185 | mrcB | VM_12185 | VM_12190 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.739 |
| VM_12185 | panB | VM_12185 | VM_12225 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.495 |
| VM_12185 | panC | VM_12185 | VM_12230 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.502 |
| VM_12185 | pcnB | VM_12185 | VM_12215 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.590 |
| VM_12185 | sfsA | VM_12185 | VM_12200 | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sugar fermentation stimulation protein SfsA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.681 |
| VM_13110 | sfsA | VM_13110 | VM_12200 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Sugar fermentation stimulation protein SfsA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.934 |
| dksA | VM_12185 | VM_12205 | VM_12185 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.632 |
| dksA | folK | VM_12205 | VM_12220 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.702 |
| dksA | gluQ | VM_12205 | VM_12210 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | tRNA glutamyl-Q synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.814 |
| dksA | hrpB | VM_12205 | VM_12195 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.686 |
| dksA | mrcB | VM_12205 | VM_12190 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.722 |
| dksA | panB | VM_12205 | VM_12225 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.702 |
| dksA | panC | VM_12205 | VM_12230 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.699 |
| dksA | pcnB | VM_12205 | VM_12215 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.740 |
| dksA | sfsA | VM_12205 | VM_12200 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Sugar fermentation stimulation protein SfsA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.825 |
| folK | VM_12185 | VM_12220 | VM_12185 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.591 |