Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
nanMN-acetylneuraminic acid mutarotase; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (383 aa)    
Predicted Functional Partners:
VM_15740
N-acetylneuraminic acid mutarotase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    
0.863
VM_15725
N-acetylneuraminate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family.
 
   
 0.710
nanE
N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
  
 0.648
VM_15685
Sialidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.629
VM_15730
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.586
nanK
N-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily.
 
   
 0.412
VM_15850
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.407
nagA-2
N-acetylglucosamine-6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.400
Your Current Organism:
Vibrio mimicus
NCBI taxonomy Id: 674
Other names: ATCC 33653, CAIM 602, CCUG 13624, CIP 101888, DSM 19130, LMG 7896, LMG:7896, NCTC 11435, V. mimicus
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