STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
N1PE59_DOTSNPKS_ER domain-containing protein. (337 aa)    
Predicted Functional Partners:
pks4
Polyketide synthase-like protein.
   
 0.621
N1PRT7_DOTSN
Uncharacterized protein.
     
 0.526
N1PX19_DOTSN
Uncharacterized protein.
     
 0.526
N1PZU6_DOTSN
Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
     
 0.526
N1Q2H4_DOTSN
Uncharacterized protein.
  
 0.496
M2WK70_DOTSN
Uncharacterized protein.
    
  0.435
pksA
Norsolorinic acid synthase; Polyketide synthase; part of the fragmented gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits hexA and hexB, as well as the polyketide synthase pksA. PksA combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR (By similarity). The hexanoyl starter unit is provided to the acyl- carr [...]
    
  0.435
dotD
Thioesterase domain-containing protein.
    
  0.435
hps1
Hybrid PKS-NRPS synthetase 1; Hybrid PKS-NRPS synthetase; part of the hps1-dma1 gene cluster that probably mediates the biosynthesis a derivative of cyclopiazonic acid (CPA) (Probable). The hybrid polyketide synthase- nonribosomal peptide synthetase (PKS-NRPS) nps1 might incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway (By similarity). In addition, the cluster also includes the tryptop [...]
    
  0.435
pks1
Polyketide synthase-like protein.
    
  0.435
Your Current Organism:
Dothistroma septosporum
NCBI taxonomy Id: 675120
Other names: D. septosporum NZE10, Dothistroma septosporum NZE10, Mycosphaerella pini NZE10
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.