node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
M2WLR6_DOTSN | M2Y4E3_DOTSN | M2WLR6 | M2Y4E3 | GTP_cyclohydroI domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.894 |
M2WLR6_DOTSN | N1PM72_DOTSN | M2WLR6 | N1PM72 | GTP_cyclohydroI domain-containing protein. | Uncharacterized protein. | 0.760 |
M2WLR6_DOTSN | N1PMJ4_DOTSN | M2WLR6 | N1PMJ4 | GTP_cyclohydroI domain-containing protein. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.708 |
M2WLR6_DOTSN | N1PWY2_DOTSN | M2WLR6 | N1PWY2 | GTP_cyclohydroI domain-containing protein. | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | 0.493 |
M2Y4E3_DOTSN | M2WLR6_DOTSN | M2Y4E3 | M2WLR6 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP_cyclohydroI domain-containing protein. | 0.894 |
M2Y4E3_DOTSN | N1PM56_DOTSN | M2Y4E3 | N1PM56 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP_cyclohydroI domain-containing protein. | 0.855 |
M2Y4E3_DOTSN | N1PM72_DOTSN | M2Y4E3 | N1PM72 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Uncharacterized protein. | 0.799 |
M2Y4E3_DOTSN | N1PMJ4_DOTSN | M2Y4E3 | N1PMJ4 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.778 |
M2Y4E3_DOTSN | N1PQJ9_DOTSN | M2Y4E3 | N1PQJ9 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. | 0.884 |
M2Y4E3_DOTSN | N1PWY2_DOTSN | M2Y4E3 | N1PWY2 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | 0.499 |
M2YKD4_DOTSN | N1PCI3_DOTSN | M2YKD4 | N1PCI3 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.887 |
M2YKD4_DOTSN | N1PM72_DOTSN | M2YKD4 | N1PM72 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Uncharacterized protein. | 0.847 |
M2YKD4_DOTSN | N1PQJ9_DOTSN | M2YKD4 | N1PQJ9 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. | 0.441 |
M2YKD4_DOTSN | N1PWY2_DOTSN | M2YKD4 | N1PWY2 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | 0.525 |
M2YKD4_DOTSN | N1Q157_DOTSN | M2YKD4 | N1Q157 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.897 |
M2YKD4_DOTSN | N1Q4R6_DOTSN | M2YKD4 | N1Q4R6 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. | 0.908 |
N1PCI3_DOTSN | M2YKD4_DOTSN | N1PCI3 | M2YKD4 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.887 |
N1PCI3_DOTSN | N1PM72_DOTSN | N1PCI3 | N1PM72 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | Uncharacterized protein. | 0.811 |
N1PCI3_DOTSN | N1Q157_DOTSN | N1PCI3 | N1Q157 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.932 |
N1PCI3_DOTSN | N1Q4R6_DOTSN | N1PCI3 | N1Q4R6 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. | 0.902 |