STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (460 aa)    
Predicted Functional Partners:
N1PE01_DOTSN
Uncharacterized protein.
    
 0.995
N1Q484_DOTSN
WD_REPEATS_REGION domain-containing protein.
   
 0.937
N1Q1E8_DOTSN
CS domain-containing protein.
    
 0.934
N1Q4V9_DOTSN
CAP-Gly domain-containing protein.
    
 0.919
N1PMK6_DOTSN
Uncharacterized protein.
    
 0.914
N1PSH5_DOTSN
Uncharacterized protein.
    
 0.913
N1PSP2_DOTSN
Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    
 0.899
N1PT53_DOTSN
Uncharacterized protein.
   
 0.841
N1PRD8_DOTSN
Uncharacterized protein.
    
 0.807
N1PU18_DOTSN
Urease domain-containing protein.
    
 0.807
Your Current Organism:
Dothistroma septosporum
NCBI taxonomy Id: 675120
Other names: D. septosporum NZE10, Dothistroma septosporum NZE10, Mycosphaerella pini NZE10
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.