Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
clpP-2ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (219 aa)    
Predicted Functional Partners:
clpP-3
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
0.987
clpX
ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 0.983
Psed_0297
Hypothetical protein.
  
 0.848
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
 
 
 0.803
Psed_4003
KEGG: nfa:nfa11310 hypothetical protein.
  
 0.791
Psed_2324
Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS; PFAM: Sporulation stage II, protein E C-terminal; ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-4; Signal transduction response regulator, receiver domain; PAS fold-3; GAF; Sulphate transporter/antisigma-factor antagonist STAS; KEGG: gob:Gobs_0116 multi-sensor signal transduction histidine kinase; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; PAC motif; Si [...]
  
 0.782
Psed_0649
3-hydroxybutyryl-CoA epimerase; KEGG: sma:SAV_1680 fatty acid oxidation complex alpha-subunit; PFAM: 3-hydroxyacyl-CoA dehydrogenase, NAD binding; Crotonase, core; 3-hydroxyacyl-CoA dehydrogenase, C-terminal.
  
 0.771
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.751
Psed_5788
PFAM: Peptidase S14, ClpP; KEGG: ppr:PBPRB1287 hypothetical protein.
  
  
  0.749
groL-2
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.743
Your Current Organism:
Pseudonocardia dioxanivorans
NCBI taxonomy Id: 675635
Other names: P. dioxanivorans CB1190, Pseudonocardia dioxanivorans CB1190, Pseudonocardia dioxanivorans DSM 44775, Pseudonocardia dioxanivorans str. CB1190, Pseudonocardia dioxanivorans strain CB1190
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