Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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nrdRTranscriptional repressor nrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (159 aa)    
Predicted Functional Partners:
Psed_3430
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.802
Psed_2125
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
     
 0.784
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
 
   
 0.692
Psed_3017
Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; Cobalamin (vitamin B12) biosynthesis CbiT, precorrin-6Y methyltransferase-core; KEGG: sgr:SGR_3528 putative methyltransferase; PFAM: Tetrapyrrole methylase.
      
 0.665
ribBA
GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.580
ribBA-2
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.580
Psed_4124
PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB; GTP cyclohydrolase II, RibA; KEGG: avn:Avin_43690 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; In the N-terminal section; belongs to the DHBP synthase family.
     
 0.580
Psed_0353
UPF0133 protein ybaB; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
  
    0.530
Psed_1561
TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: CinA, C-terminal; Molybdopterin binding; KEGG: mkm:Mkms_2751 competence damage-inducible protein A; SMART: Molybdopterin binding; Belongs to the CinA family.
  
    0.529
Psed_3023
TIGRFAM: Cobaltochelatase, CobN subunit; KEGG: req:REQ_23600 cobaltochelatase CobN; PFAM: CobN/magnesium chelatase.
      
 0.523
Your Current Organism:
Pseudonocardia dioxanivorans
NCBI taxonomy Id: 675635
Other names: P. dioxanivorans CB1190, Pseudonocardia dioxanivorans CB1190, Pseudonocardia dioxanivorans DSM 44775, Pseudonocardia dioxanivorans str. CB1190, Pseudonocardia dioxanivorans strain CB1190
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